InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Meis1

Summary

InnateDB Gene

IDBG-152330.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Meis1

Gene Name

Meis homeobox 1

Synonyms

C530044H18Rik; Evi8

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020160

Encoded Proteins

IDBP-152332

Meis homeobox 1

IDBP-152334

Meis homeobox 1

IDBP-717403

IDBP-789804

Meis homeobox 1

IDBP-718082

IDBP-789805

Meis homeobox 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143995:
Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. [provided by RefSeq, Jul 2008]
Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE (\'three amino acid loop extension\') family of homeodomain-containing proteins. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:18879817-19018985

Strand

Reverse strand

Band

A3.1

Transcripts

ENSMUST00000102878	ENSMUSP00000099942
ENSMUST00000068264	ENSMUSP00000069277
ENSMUST00000118661
ENSMUST00000144988	ENSMUSP00000134969
ENSMUST00000125722
ENSMUST00000137300
ENSMUST00000177357	ENSMUSP00000139074
ENSMUST00000177417	ENSMUSP00000135726
ENSMUST00000185131	ENSMUSP00000139219

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	29 [view]
Protein-Protein	25 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001525	angiogenesis
GO:0002089	lens morphogenesis in camera-type eye
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0030097	hemopoiesis
GO:0035855	megakaryocyte development
GO:0045638	negative regulation of myeloid cell differentiation
GO:0045665	negative regulation of neuron differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048514	blood vessel morphogenesis
GO:0060216	definitive hemopoiesis

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex

Orthologs

Species

Homo sapiens

Gene ID

Gene Order

ENSG00000143995

View Gene Order

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

17268

UniGene

RefSeq

NM_001193271 NM_010789 XM_006514562

OMIM

CCDS

CCDS24453 CCDS56760

HPRD

IMGT

MGI ID

MGI:104717

MGI Symbol

Meis1

EMBL

GenPept

RNA Seq Atlas

17268