Version 5.4
Homo sapiens Gene: MEIS1
Summary
InnateDB Gene IDBG-54348.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MEIS1
Gene Name Meis homeobox 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000143995
Encoded Proteins
IDBP-54350
Meis homeobox 1
IDBP-232934
Meis homeobox 1
IDBP-378021
Meis homeobox 1
IDBP-809915
Meis homeobox 1
IDBP-588432
Meis homeobox 1
IDBP-603826
Meis homeobox 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. [provided by RefSeq, Jul 2008]
Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE (\'three amino acid loop extension\') family of homeodomain-containing proteins. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:66433452-66573869
Strand Forward strand
Band p14
Transcripts
ENST00000272369 ENSP00000272369
ENST00000398506 ENSP00000381518
ENST00000409622
ENST00000409517
ENST00000437869 ENSP00000397418
ENST00000450027
ENST00000496248
ENST00000491706
ENST00000488550 ENSP00000475161
ENST00000490726
ENST00000466811
ENST00000498705
ENST00000475239
ENST00000495021 ENSP00000440571
ENST00000560281 ENSP00000454209
ENST00000542964
ENST00000606455
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 17 [view]
Protein-DNA 8 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0001525 angiogenesis
GO:0002089 lens morphogenesis in camera-type eye
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007275 multicellular organismal development
GO:0030097 hemopoiesis
GO:0035855 megakaryocyte development
GO:0045638 negative regulation of myeloid cell differentiation
GO:0045665 negative regulation of neuron differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048514 blood vessel morphogenesis
GO:0060216 definitive hemopoiesis
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000020160
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 4211
UniGene Hs.661871
RefSeq NM_002398 XM_005264324 XM_005264325
HUGO HGNC:7000
OMIM 601739
CCDS CCDS46309
HPRD 03442
IMGT
EMBL
GenPept
RNA Seq Atlas 4211

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca