Mus musculus Gene: Bcam
Summary
InnateDB Gene IDBG-152453.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Bcam
Gene Name basal cell adhesion molecule
Synonyms 1200005K12Rik; B-CAM; Gplu; Lu;
Species Mus musculus
Ensembl Gene ENSMUSG00000002980
Encoded Proteins
basal cell adhesion molecule
basal cell adhesion molecule
basal cell adhesion molecule
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000187244:
This gene encodes Lutheran blood group glycoprotein, a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five extracellular immunoglobulin domains, a single transmembrane domain, and a short C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Polymorphisms in this gene define some of the antigens in the Lutheran system and also the Auberger system. Inactivating variants of this gene result in the recessive Lutheran null phenotype, Lu(a-b-), of the Lutheran blood group. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:19756131-19771016
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000003061 ENSMUSP00000003061
ENSMUST00000135632
ENSMUST00000133271
ENSMUST00000155244 ENSMUSP00000121145
ENSMUST00000133427 ENSMUSP00000117998
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005055 laminin receptor activity
GO:0005515 protein binding
GO:0043236 laminin binding
Biological Process
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.29236
RefSeq NM_020486 XM_006540237
OMIM
CCDS CCDS39803
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas