Homo sapiens Gene: BCAM
Summary
InnateDB Gene IDBG-56639.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BCAM
Gene Name basal cell adhesion molecule (Lutheran blood group)
Synonyms AU; CD239; LU; MSK19;
Species Homo sapiens
Ensembl Gene ENSG00000187244
Encoded Proteins
basal cell adhesion molecule (Lutheran blood group)
basal cell adhesion molecule (Lutheran blood group)
basal cell adhesion molecule (Lutheran blood group)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes Lutheran blood group glycoprotein, a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five extracellular immunoglobulin domains, a single transmembrane domain, and a short C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Polymorphisms in this gene define some of the antigens in the Lutheran system and also the Auberger system. Inactivating variants of this gene result in the recessive Lutheran null phenotype, Lu(a-b-), of the Lutheran blood group. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:44809059-44821420
Strand Forward strand
Band q13.32
Transcripts
ENST00000270233 ENSP00000270233
ENST00000588603
ENST00000590108
ENST00000591520 ENSP00000467100
ENST00000590196 ENSP00000468189
ENST00000589651 ENSP00000476710
ENST00000590624
ENST00000588303
ENST00000589558
ENST00000588714
ENST00000611077 ENSP00000481153
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0005055 laminin receptor activity
GO:0005515 protein binding
GO:0043236 laminin binding
Biological Process
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007165 signal transduction
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt P50895
TrEMBL A9YWT4
UniProt Splice Variant
Entrez Gene 4059
UniGene Hs.625725
RefSeq NM_005581 NM_001013257
HUGO HGNC:6722
OMIM 612773
CCDS CCDS12644 CCDS42575
HPRD 00197
IMGT
EMBL AC092306 AY845133 BC050450 CH471126 EU307107 EU307108 EU307109 X80026 X83425
GenPept AAH50450 AAV88096 ABY27635 ABY27636 ABY27637 CAA56327 CAA58449 EAW57297
RNA Seq Atlas 4059