InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Bcap31

Summary

InnateDB Gene

IDBG-153364.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bcap31

Gene Name

B cell receptor associated protein 31

Synonyms

Bap31

Species

Mus musculus

Ensembl Gene

ENSMUSG00000002015

Encoded Proteins

IDBP-153366

B-cell receptor-associated protein 31

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185825:
This gene encodes a member of the B-cell receptor associated protein 31 superfamily. The encoded protein is a multi-pass transmembrane protein of the endoplasmic reticulum that is involved in the anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi and in caspase 8-mediated apoptosis. Microdeletions in this gene are associated with contiguous ABCD1/DXS1375E deletion syndrome (CADDS), a neonatal disorder. Alternative splicing of this gene results in multiple transcript variants. Two related pseudogenes have been identified on chromosome 16. [provided by RefSeq, Jan 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:73686178-73716175

Strand

Reverse strand

Band

A7.3

Transcripts

ENSMUST00000002091

ENSMUSP00000002091

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	33 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0032403	protein complex binding
GO:0042288	MHC class I protein binding

Biological Process

GO:0006886	intracellular protein transport
GO:0006888	ER to Golgi vesicle-mediated transport
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007283	spermatogenesis
GO:0032471	negative regulation of endoplasmic reticulum calcium ion concentration
GO:0035584	calcium-mediated signaling using intracellular calcium source
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0051561	positive regulation of mitochondrial calcium ion concentration
GO:0070973	protein localization to endoplasmic reticulum exit site
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0000139	Golgi membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005811	lipid particle
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030136	clathrin-coated vesicle
GO:0032580	Golgi cisterna membrane
GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane