InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bcap31

Summary

InnateDB Protein

IDBP-153366.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bcap31

Protein Name

B-cell receptor-associated protein 31

Synonyms

Bap31;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000002091

InnateDB Gene

IDBG-153364 (Bcap31)

Protein Structure

UniProt Annotation

Function

Functions as a chaperone protein. Is one of the most abundant endoplasmic reticulum (ER) proteins. Plays a role in the export of secreted proteins in the ER, the recognition of abnormally folded protein and their targeting to the ER associated-degradation (ERAD). Also serves as a cargo receptor for the export of transmembrane proteins. May be involved in CASP8- mediated apoptosis. {ECO:0000269PubMed:15187134, ECO:0000269PubMed:9396746}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=May shuttle between the ER and the intermediate compartment/cis-Golgi complex. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:8612576}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	33 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0032403	protein complex binding
GO:0042288	MHC class I protein binding

Biological Process

GO:0006886	intracellular protein transport
GO:0006888	ER to Golgi vesicle-mediated transport
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007283	spermatogenesis
GO:0032471	negative regulation of endoplasmic reticulum calcium ion concentration
GO:0035584	calcium-mediated signaling using intracellular calcium source
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0051561	positive regulation of mitochondrial calcium ion concentration
GO:0070973	protein localization to endoplasmic reticulum exit site
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0000139	Golgi membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005811	lipid particle
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030136	clathrin-coated vesicle
GO:0032580	Golgi cisterna membrane
GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane