InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Abcd1

Summary

InnateDB Gene

IDBG-153430.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Abcd1

Gene Name

ATP-binding cassette, sub-family D (ALD), member 1

Synonyms

Ald; Aldgh; ALDP

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031378

Encoded Proteins

IDBP-153432

ATP-binding cassette, sub-family D (ALD), member 1

IDBP-251724

ATP-binding cassette, sub-family D (ALD), member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein is likely involved in the peroxisomal transport or catabolism of very long chain fatty acids. Defects in the human gene have been identified as the underlying cause of adrenoleukodystrophy, an X-chromosome recessively inherited demyelinating disorder of the nervous system. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:73716597-73738534

Strand

Forward strand

Band

A7.3

Transcripts

ENSMUST00000002084	ENSMUSP00000002084
ENSMUST00000114461	ENSMUSP00000110105

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005325	peroxisomal fatty-acyl-CoA transporter activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0019899	enzyme binding
GO:0042626	ATPase activity, coupled to transmembrane movement of substances
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006200	ATP catabolic process
GO:0006635	fatty acid beta-oxidation
GO:0006810	transport
GO:0015910	peroxisomal long-chain fatty acid import
GO:0042758	long-chain fatty acid catabolic process
GO:0042760	very long-chain fatty acid catabolic process
GO:0055085	transmembrane transport

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005777	peroxisome
GO:0005778	peroxisomal membrane
GO:0005779	integral component of peroxisomal membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0048471	perinuclear region of cytoplasm