InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Slc25a4

Summary

InnateDB Gene

IDBG-153787.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc25a4

Gene Name

solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4

Synonyms

Ant1; AU019225

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031633

Encoded Proteins

IDBP-153789

solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000151729:
This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Mutations in this gene have been shown to result in autosomal dominant progressive external opthalmoplegia and familial hypertrophic cardiomyopathy. [provided by RefSeq, Sep 2009]
This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Mutations in this gene have been shown to result in autosomal dominant progressive external opthalmoplegia and familial hypertrophic cardiomyopathy. [provided by RefSeq, Jun 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:46206797-46211284

Strand

Reverse strand

Band

B1.1

Transcripts

ENSMUST00000034049	ENSMUSP00000034049
ENSMUST00000155986

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005515	protein binding

Biological Process

GO:0008637	apoptotic mitochondrial changes
GO:0055085	transmembrane transport
GO:0060546	negative regulation of necroptotic process
GO:0060547	negative regulation of necrotic cell death

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005743	mitochondrial inner membrane
GO:0016021	integral component of membrane