InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SLC25A4

Summary

InnateDB Gene

IDBG-46664.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC25A4

Gene Name

solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4

Synonyms

1; AAC1; ANT; ANT 1; ANT1; MTDPS12; PEO2; PEO3; T1

Species

Homo sapiens

Ensembl Gene

ENSG00000151729

Encoded Proteins

IDBP-46666

solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4

IDBP-811901

solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Mutations in this gene have been shown to result in autosomal dominant progressive external opthalmoplegia and familial hypertrophic cardiomyopathy. [provided by RefSeq, Sep 2009]
This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Mutations in this gene have been shown to result in autosomal dominant progressive external opthalmoplegia and familial hypertrophic cardiomyopathy. [provided by RefSeq, Jun 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:185143241-185150382

Strand

Forward strand

Band

q35.1

Transcripts

ENST00000281456	ENSP00000281456
ENST00000491736	ENSP00000476711

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	33 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0015207	adenine transmembrane transporter activity

Biological Process

GO:0000002	mitochondrial genome maintenance
GO:0006091	generation of precursor metabolites and energy
GO:0006112	energy reserve metabolic process
GO:0006810	transport
GO:0008637	apoptotic mitochondrial changes
GO:0015853	adenine transport
GO:0016032	viral process
GO:0044281	small molecule metabolic process
GO:0050796	regulation of insulin secretion
GO:0055085	transmembrane transport
GO:0060546	negative regulation of necroptotic process

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane