InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Apba1

Summary

InnateDB Gene

IDBG-154300.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Apba1

Gene Name

amyloid beta (A4) precursor protein binding, family A, member 1

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024897

Encoded Proteins

IDBP-154302

amyloid beta (A4) precursor protein binding, family A, member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000107282:
The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer\'s disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer\'s disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:23758876-23949597

Strand

Forward strand

Band

Transcripts

ENSMUST00000025830

ENSMUSP00000025830

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001540	beta-amyloid binding
GO:0005515	protein binding
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
GO:0030165	PDZ domain binding
GO:0032403	protein complex binding

Biological Process

GO:0001701	in utero embryonic development
GO:0006886	intracellular protein transport
GO:0007268	synaptic transmission
GO:0007626	locomotory behavior
GO:0010468	regulation of gene expression
GO:0014047	glutamate secretion
GO:0014051	gamma-aminobutyric acid secretion
GO:0035264	multicellular organism growth

Cellular Component

GO:0005634	nucleus
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0043234	protein complex
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000107282

View Gene Order

ENSBTAG00000008877

Not yet available

Cross-References

SwissProt

B2RUJ5

TrEMBL

UniProt Splice Variant

Entrez Gene

319924

UniGene

Mm.22879

RefSeq

NM_177034 XM_006527139

OMIM

CCDS

CCDS50407

HPRD

IMGT

MGI ID

MGI:1860297

MGI Symbol

Apba1

EMBL

AC134830 AC148021 AK032261 AK147583 BC141181 CH466534

GenPept

AAI41182 BAC27784 BAE28008 EDL41607 EDL41608

RNA Seq Atlas

319924