Homo sapiens Gene: APBA1
Summary
InnateDB Gene IDBG-69588.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol APBA1
Gene Name amyloid beta (A4) precursor protein-binding, family A, member 1
Synonyms D9S411E; LIN10; MINT1; X11; X11A; X11ALPHA;
Species Homo sapiens
Ensembl Gene ENSG00000107282
Encoded Proteins
amyloid beta (A4) precursor protein-binding, family A, member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer\'s disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer\'s disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:69427530-69672306
Strand Reverse strand
Band q21.12
Transcripts
ENST00000265381 ENSP00000265381
ENST00000470082
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001540 beta-amyloid binding
GO:0005515 protein binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0030165 PDZ domain binding
GO:0032403 protein complex binding
Biological Process
GO:0001701 in utero embryonic development
GO:0006461 protein complex assembly
GO:0006886 intracellular protein transport
GO:0007155 cell adhesion
GO:0007268 synaptic transmission
GO:0007399 nervous system development
GO:0007626 locomotory behavior
GO:0008088 axon cargo transport
GO:0010468 regulation of gene expression
GO:0014047 glutamate secretion
GO:0014051 gamma-aminobutyric acid secretion
GO:0035264 multicellular organism growth
Cellular Component
GO:0005634 nucleus
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0008021 synaptic vesicle
GO:0016020 membrane
GO:0043234 protein complex
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt Q02410
TrEMBL
UniProt Splice Variant
Entrez Gene 320
UniGene Hs.171939 Hs.592974
RefSeq NM_001163 XM_005251967 XM_006717093
HUGO HGNC:578
OMIM 602414
CCDS CCDS6630
HPRD 03879
IMGT
EMBL AF029106 AF047347 AL353693 AL355140 L04953
GenPept AAA61307 AAC05304 AAC39766 CAH74104 CAI15443
RNA Seq Atlas 320