InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: APBA1

Summary

InnateDB Gene

IDBG-69588.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APBA1

Gene Name

amyloid beta (A4) precursor protein-binding, family A, member 1

Synonyms

D9S411E; LIN10; MINT1; X11; X11A; X11ALPHA

Species

Homo sapiens

Ensembl Gene

ENSG00000107282

Encoded Proteins

IDBP-69590

amyloid beta (A4) precursor protein-binding, family A, member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer\'s disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer\'s disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:69427530-69672306

Strand

Reverse strand

Band

q21.12

Transcripts

ENST00000265381	ENSP00000265381
ENST00000470082

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001540	beta-amyloid binding
GO:0005515	protein binding
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
GO:0030165	PDZ domain binding
GO:0032403	protein complex binding

Biological Process

GO:0001701	in utero embryonic development
GO:0006461	protein complex assembly
GO:0006886	intracellular protein transport
GO:0007155	cell adhesion
GO:0007268	synaptic transmission
GO:0007399	nervous system development
GO:0007626	locomotory behavior
GO:0008088	axon cargo transport
GO:0010468	regulation of gene expression
GO:0014047	glutamate secretion
GO:0014051	gamma-aminobutyric acid secretion
GO:0035264	multicellular organism growth

Cellular Component

GO:0005634	nucleus
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0008021	synaptic vesicle
GO:0016020	membrane
GO:0043234	protein complex
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000024897

View Gene Order

ENSBTAG00000008877

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.171939 Hs.592974

RefSeq

NM_001163 XM_005251967 XM_006717093

HUGO

OMIM

CCDS

CCDS6630

HPRD

03879

IMGT

EMBL

GenPept

RNA Seq Atlas