Version 5.4
Mus musculus Gene: Unc5a
Summary
InnateDB Gene IDBG-154478.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Unc5a
Gene Name unc-5 homolog A (C. elegans)
Synonyms mKIAA1976; Unc5h1
Species Mus musculus
Ensembl Gene ENSMUSG00000025876
Encoded Proteins
IDBP-154480
unc-5 homolog A (C. elegans)
IDBP-261199
unc-5 homolog A (C. elegans)
IDBP-532993
unc-5 homolog A (C. elegans)
IDBP-539570
unc-5 homolog A (C. elegans)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113763:
UNC5A belongs to a family of netrin-1 (MIM 601614) receptors thought to mediate the chemorepulsive effect of netrin-1 on specific axons. For more information on UNC5 proteins, see UNC5C (MIM 603610).[supplied by OMIM, Apr 2004]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:54949411-55006018
Strand Forward strand
Band B1
Transcripts
ENSMUST00000026994 ENSMUSP00000026994
ENSMUST00000109994 ENSMUSP00000105621
ENSMUST00000136852 ENSMUSP00000116585
ENSMUST00000142906
ENSMUST00000137967 ENSMUSP00000115531
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0033564 anterior/posterior axon guidance
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000113763
View Gene Order
ENSBTAG00000014897
Not yet available
Pathways
NETPATH
REACTOME
REACT_258521
Apoptosis pathway
REACT_229826
Netrin-1 signaling pathway
REACT_252543
Role of DCC in regulating apoptosis pathway
REACT_227606
Regulation of Apoptosis pathway
REACT_261444
Axon guidance pathway
REACT_188576
Developmental Biology pathway
REACT_253341
Netrin mediated repulsion signals pathway
KEGG
mmu04360
Axon guidance pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_22128
Role of DCC in regulating apoptosis pathway
REACT_22384
Netrin mediated repulsion signals pathway
REACT_22237
Netrin-1 signaling pathway
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
REACT_578
Apoptosis pathway
REACT_13648
Regulation of Apoptosis pathway
KEGG
hsa04360
Axon guidance pathway
INOH
PID NCI
netrin_pathway
Netrin-mediated signaling events
Cross-References
SwissProt Q8K1S4
TrEMBL
UniProt Splice Variant
Entrez Gene 107448
UniGene
RefSeq NM_153131 XM_006517037 XM_006517040 XM_006517038 XM_006517039
OMIM
CCDS CCDS26537
HPRD
IMGT
MGI ID MGI:894682
MGI Symbol Unc5a
EMBL AJ487852 AK122575 BC058084
GenPept AAH58084 BAC65857 CAD32250
RNA Seq Atlas 107448

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca