Mus musculus Gene: Arhgef12
Summary
InnateDB Gene IDBG-154794.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arhgef12
Gene Name Rho guanine nucleotide exchange factor (GEF) 12
Synonyms 2310014B11Rik; AU019857; Larg; mKIAA0382;
Species Mus musculus
Ensembl Gene ENSMUSG00000059495
Encoded Proteins
Rho guanine nucleotide exchange factor (GEF) 12
Rho guanine nucleotide exchange factor (GEF) 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196914:
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:42963842-43105718
Strand Reverse strand
Band A5.1
Transcripts
ENSMUST00000072767 ENSMUSP00000072547
ENSMUST00000165665 ENSMUSP00000126598
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001664 G-protein coupled receptor binding
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005096 GTPase activator activity
GO:0005515 protein binding
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0032319 regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
GO:0038032 termination of G-protein coupled receptor signaling pathway
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
GPCR downstream signaling pathway
Signaling by GPCR pathway
NRAGE signals death through JNK pathway
Signaling by Rho GTPases pathway
Sema4D induced cell migration and growth-cone collapse pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
G alpha (12/13) signalling events pathway
Axon guidance pathway
Rho GTPase cycle pathway
Sema4D in semaphorin signaling pathway
Signalling by NGF pathway
Developmental Biology pathway
Semaphorin interactions pathway
Signal Transduction pathway
p75 NTR receptor-mediated signalling pathway
KEGG
Vascular smooth muscle contraction pathway
Axon guidance pathway
Regulation of actin cytoskeleton pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Sema4D in semaphorin signaling pathway
G alpha (12/13) signalling events pathway
Developmental Biology pathway
Signalling by NGF pathway
Semaphorin interactions pathway
Signaling by Rho GTPases pathway
Signaling by GPCR pathway
Axon guidance pathway
p75 NTR receptor-mediated signalling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
NRAGE signals death through JNK pathway
Rho GTPase cycle pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
Sema4D induced cell migration and growth-cone collapse pathway
KEGG
Vascular smooth muscle contraction pathway
Axon guidance pathway
Regulation of actin cytoskeleton pathway
INOH
PID BIOCARTA
PID NCI
Regulation of RhoA activity
Cross-References
SwissProt Q8R4H2
TrEMBL
UniProt Splice Variant
Entrez Gene 69632
UniGene Mm.275266 Mm.415694 Mm.450945 Mm.458711 Mm.463041 Mm.465166 Mm.475265 Mm.484650
RefSeq XM_001473524 XM_006535879 NM_027144 XM_006510586
OMIM
CCDS CCDS40595
HPRD
IMGT
MGI ID MGI:1916882
MGI Symbol Arhgef12
EMBL AC110169 AC160123 AF467766 AK122267
GenPept AAL87100 BAC65549
RNA Seq Atlas 69632