InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Arhgef12

Summary

InnateDB Gene

IDBG-154794.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Arhgef12

Gene Name

Rho guanine nucleotide exchange factor (GEF) 12

Synonyms

2310014B11Rik; AU019857; Larg; mKIAA0382

Species

Mus musculus

Ensembl Gene

ENSMUSG00000059495

Encoded Proteins

IDBP-154796

Rho guanine nucleotide exchange factor (GEF) 12

IDBP-625927

Rho guanine nucleotide exchange factor (GEF) 12

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196914:
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:42963842-43105718

Strand

Reverse strand

Band

A5.1

Transcripts

ENSMUST00000072767	ENSMUSP00000072547
ENSMUST00000165665	ENSMUSP00000126598

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005096	GTPase activator activity
GO:0005515	protein binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0032319	regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0043547	positive regulation of GTPase activity