InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Arhgef12

Summary

InnateDB Protein

IDBP-154796.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Arhgef12

Protein Name

Rho guanine nucleotide exchange factor (GEF) 12

Synonyms

2310014B11Rik; AU019857; Larg; mKIAA0382;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000072547

InnateDB Gene

IDBG-154794 (Arhgef12)

Protein Structure

UniProt Annotation

Function

May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13 (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000305}. Membrane {ECO:0000305}. Note=Translocated to the membrane upon stimulation. {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in brain, predominantly in neuronal cell bodies. {ECO:0000269PubMed:12492428}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005096	GTPase activator activity
GO:0005515	protein binding

Biological Process

GO:0032319	regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0043547	positive regulation of GTPase activity

Cellular Component

GO:0005737	cytoplasm
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:1916882

InterPro

IPR000219 Dbl homology (DH) domain
IPR001478 PDZ domain
IPR001849 Pleckstrin homology domain
IPR015212 Regulator of G protein signalling-like domain
IPR016137 Regulator of G protein signalling superfamily

PFAM

PF00621
PF00595
PF13180
PF00169
PF09128

PRINTS

PIRSF

SMART

SM00325
SM00228
SM00233
SM00315

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8R4H2