Version 5.4
Mus musculus Gene: Dock8
Summary
InnateDB Gene IDBG-154888.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dock8
Gene Name dedicator of cytokinesis 8
Synonyms 1200017A24Rik; 5830472H07Rik; A130095G14Rik; AI461977
Species Mus musculus
Ensembl Gene ENSMUSG00000052085
Encoded Proteins
IDBP-154890
dedicator of cytokinesis 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000107099:
This gene encodes a member of the DOCK180 family of guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with Rho GTPases and are components of intracellular signaling networks. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:24999529-25202432
Strand Forward strand
Band B
Transcripts
ENSMUST00000025831 ENSMUSP00000025831
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0001771 immunological synapse formation
GO:0007264 small GTPase mediated signal transduction
GO:0036336 dendritic cell migration
GO:0043087 regulation of GTPase activity
GO:0061485 memory T cell proliferation
GO:0070233 negative regulation of T cell apoptotic process
Cellular Component
GO:0016020 membrane
GO:0031252 cell leading edge
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000107099
View Gene Order
ENSBTAG00000002190
Not yet available
Pathways
NETPATH
REACTOME
REACT_224553
Hemostasis pathway
REACT_198649
Factors involved in megakaryocyte development and platelet production pathway
KEGG
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_604
Hemostasis pathway
KEGG
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
Cross-References
SwissProt Q8C147
TrEMBL Q8CBT1
UniProt Splice Variant
Entrez Gene 76088
UniGene Mm.102485
RefSeq NM_028785 XM_006527435 XM_006527436
OMIM
CCDS CCDS37943
HPRD
IMGT
MGI ID MGI:1921396
MGI Symbol Dock8
EMBL AC132319 AC139711 AK004816 AK028968 AK035336 AK038285 AK131180 BC029018 BC030316 BC043470 BC055295
GenPept AAH29018 AAH30316 AAH43470 AAH55295 BAB23587 BAC26219 BAC29037 BAC29959 BAD21430
RNA Seq Atlas 76088

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca