Version 5.4
Homo sapiens Gene: DOCK8
Summary
InnateDB Gene IDBG-43444.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DOCK8
Gene Name dedicator of cytokinesis 8
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000107099
Encoded Proteins
IDBP-43454
dedicator of cytokinesis 8
IDBP-43456
dedicator of cytokinesis 8
IDBP-361348
dedicator of cytokinesis 8
IDBP-361350
dedicator of cytokinesis 8
IDBP-477287
dedicator of cytokinesis 8
IDBP-473739
dedicator of cytokinesis 8
IDBP-480098
dedicator of cytokinesis 8
IDBP-484133
dedicator of cytokinesis 8
IDBP-484109
dedicator of cytokinesis 8
IDBP-588163
dedicator of cytokinesis 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the DOCK180 family of guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with Rho GTPases and are components of intracellular signaling networks. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:214854-465259
Strand Forward strand
Band p24.3
Transcripts
ENST00000382341
ENST00000382331 ENSP00000371768
ENST00000382329 ENSP00000371766
ENST00000454469
ENST00000453981 ENSP00000408464
ENST00000432829 ENSP00000394888
ENST00000469197 ENSP00000418587
ENST00000479404 ENSP00000417082
ENST00000487230 ENSP00000418318
ENST00000483757 ENSP00000417691
ENST00000478380
ENST00000469391 ENSP00000419438
ENST00000495184
ENST00000474772
ENST00000493666
ENST00000462618
ENST00000524396 ENSP00000436628
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 24 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0001771 immunological synapse formation
GO:0007264 small GTPase mediated signal transduction
GO:0007596 blood coagulation
GO:0036336 dendritic cell migration
GO:0043547 positive regulation of GTPase activity
GO:0061485 memory T cell proliferation
GO:0070233 negative regulation of T cell apoptotic process
Cellular Component
GO:0005829 cytosol
GO:0016020 membrane
GO:0031252 cell leading edge
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000052085
View Gene Order
ENSBTAG00000002190
Not yet available
Pathways
NETPATH
REACTOME
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_604
Hemostasis pathway
KEGG
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL A2A369 V9HVZ1
UniProt Splice Variant
Entrez Gene 81704
UniGene Hs.132599 Hs.629467 Hs.734892
RefSeq NM_001190458 NM_001193536 NM_203447
HUGO HGNC:19191
OMIM 611432
CCDS CCDS55283 CCDS55284 CCDS6440
HPRD 10920
IMGT
EMBL AL158832 AL161725 EU668358
GenPept ACF94511
RNA Seq Atlas 81704

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca