InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rgs14

Summary

InnateDB Gene

IDBG-155453.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rgs14

Gene Name

regulator of G-protein signaling 14

Synonyms

RPIP1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000052087

Encoded Proteins

IDBP-155455

regulator of G-protein signaling 14

IDBP-534448

regulator of G-protein signaling 14

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169220:
This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:55369732-55384687

Strand

Forward strand

Band

Transcripts

ENSMUST00000063771	ENSMUSP00000068731
ENSMUST00000149858	ENSMUSP00000121508
ENSMUST00000135851

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001965	G-protein alpha-subunit binding
GO:0005057	receptor signaling protein activity
GO:0005092	GDP-dissociation inhibitor activity
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0019901	protein kinase binding
GO:0030159	receptor signaling complex scaffold activity
GO:0030695	GTPase regulator activity
GO:0032794	GTPase activating protein binding

Biological Process

GO:0006913	nucleocytoplasmic transport
GO:0006979	response to oxidative stress
GO:0007051	spindle organization
GO:0007059	chromosome segregation
GO:0007067	mitotic nuclear division
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007612	learning
GO:0007616	long-term memory
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0008542	visual learning
GO:0010070	zygote asymmetric cell division
GO:0031914	negative regulation of synaptic plasticity
GO:0035556	intracellular signal transduction
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0043407	negative regulation of MAP kinase activity
GO:0043547	positive regulation of GTPase activity
GO:0043620	regulation of DNA-dependent transcription in response to stress
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0050769	positive regulation of neurogenesis
GO:0051301	cell division
GO:0060291	long-term synaptic potentiation
GO:0070373	negative regulation of ERK1 and ERK2 cascade

Cellular Component

GO:0000922	spindle pole
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005819	spindle
GO:0005874	microtubule
GO:0005886	plasma membrane
GO:0014069	postsynaptic density
GO:0016604	nuclear body
GO:0016605	PML body
GO:0030054	cell junction
GO:0030425	dendrite
GO:0043197	dendritic spine
GO:0045111	intermediate filament cytoskeleton
GO:0045211	postsynaptic membrane