Version 5.4
Homo sapiens Gene: RGS14
Summary
InnateDB Gene IDBG-59816.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RGS14
Gene Name regulator of G-protein signaling 14
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000169220
Encoded Proteins
IDBP-294859
regulator of G-protein signaling 14
IDBP-482808
regulator of G-protein signaling 14
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:177357837-177372601
Strand Forward strand
Band q35.3
Transcripts
ENST00000408923 ENSP00000386229
ENST00000425155
ENST00000504631
ENST00000511890 ENSP00000422329
ENST00000514713
ENST00000503110
ENST00000512000
ENST00000512490
ENST00000502731
ENST00000514102
ENST00000509289
ENST00000503044
ENST00000506944
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 22 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001965 G-protein alpha-subunit binding
GO:0005057 receptor signaling protein activity
GO:0005092 GDP-dissociation inhibitor activity
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0019901 protein kinase binding
GO:0030159 receptor signaling complex scaffold activity
GO:0030695 GTPase regulator activity
GO:0032794 GTPase activating protein binding
Biological Process
GO:0006913 nucleocytoplasmic transport
GO:0006979 response to oxidative stress
GO:0007051 spindle organization
GO:0007059 chromosome segregation
GO:0007067 mitotic nuclear division
GO:0007165 signal transduction
GO:0007612 learning
GO:0007616 long-term memory
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0008542 visual learning
GO:0010070 zygote asymmetric cell division
GO:0031914 negative regulation of synaptic plasticity
GO:0035556 intracellular signal transduction
GO:0038032 termination of G-protein coupled receptor signaling pathway
GO:0043407 negative regulation of MAP kinase activity
GO:0043547 positive regulation of GTPase activity
GO:0043620 regulation of DNA-dependent transcription in response to stress
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0050769 positive regulation of neurogenesis
GO:0051301 cell division
GO:0060291 long-term synaptic potentiation
GO:0070373 negative regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005819 spindle
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0014069 postsynaptic density
GO:0016604 nuclear body
GO:0016605 PML body
GO:0030054 cell junction
GO:0030425 dendrite
GO:0043197 dendritic spine
GO:0045211 postsynaptic membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000052087
View Gene Order
ENSBTAG00000008497
Not yet available
Pathways
NETPATH
REACTOME
REACT_19231
G alpha (i) signalling events pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
KEGG
INOH
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.9347
RefSeq NM_006480 XM_005265794
HUGO
OMIM
CCDS CCDS43405
HPRD 03944
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca