Mus musculus Gene: Grk6
Summary
InnateDB Gene IDBG-155760.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Grk6
Gene Name G protein-coupled receptor kinase 6
Synonyms Gprk6;
Species Mus musculus
Ensembl Gene ENSMUSG00000074886
Encoded Proteins
G protein-coupled receptor kinase 6
G protein-coupled receptor kinase 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198055:
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:55445334-55460925
Strand Forward strand
Band B1
Transcripts
ENSMUST00000099482 ENSMUSP00000097081
ENSMUST00000001115 ENSMUSP00000001115
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004703 G-protein coupled receptor kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0016055 Wnt signaling pathway
GO:0038032 termination of G-protein coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Chemokine signaling pathway pathway
Endocytosis pathway
INOH
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
FSH pathway
REACTOME
KEGG
Chemokine signaling pathway pathway
Endocytosis pathway
INOH
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
PID BIOCARTA
PID NCI
CXCR4-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.10193
RefSeq NM_001038018 NM_001112711 NM_001286063 NM_001286064 NM_001286066 NM_011938 XM_006517251 XM_006517252
OMIM
CCDS CCDS36676 CCDS49272
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas