InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Grk6

Summary

InnateDB Gene

IDBG-155760.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Grk6

Gene Name

G protein-coupled receptor kinase 6

Synonyms

Gprk6

Species

Mus musculus

Ensembl Gene

ENSMUSG00000074886

Encoded Proteins

IDBP-155762

G protein-coupled receptor kinase 6

IDBP-155764

G protein-coupled receptor kinase 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198055:
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:55445334-55460925

Strand

Forward strand

Band

Transcripts

ENSMUST00000099482	ENSMUSP00000097081
ENSMUST00000001115	ENSMUSP00000001115

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004703	G-protein coupled receptor kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0016055	Wnt signaling pathway
GO:0038032	termination of G-protein coupled receptor signaling pathway