InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GRK6

Summary

InnateDB Gene

IDBG-60027.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GRK6

Gene Name

G protein-coupled receptor kinase 6

Synonyms

GPRK6

Species

Homo sapiens

Ensembl Gene

ENSG00000198055

Encoded Proteins

IDBP-60029

G protein-coupled receptor kinase 6

IDBP-60031

G protein-coupled receptor kinase 6

IDBP-243328

G protein-coupled receptor kinase 6

IDBP-473996

G protein-coupled receptor kinase 6

IDBP-485116

G protein-coupled receptor kinase 6

IDBP-479594

G protein-coupled receptor kinase 6

IDBP-483044

G protein-coupled receptor kinase 6

IDBP-474320

G protein-coupled receptor kinase 6

IDBP-480057

G protein-coupled receptor kinase 6

IDBP-587559

G protein-coupled receptor kinase 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:177403204-177442901

Strand

Forward strand

Band

q35.3

Transcripts

ENST00000355472	ENSP00000347655
ENST00000355958	ENSP00000348230
ENST00000393576	ENSP00000377204
ENST00000502598	ENSP00000422873
ENST00000506296	ENSP00000421055
ENST00000511244	ENSP00000425391
ENST00000507633	ENSP00000427581
ENST00000512684	ENSP00000422342
ENST00000515666
ENST00000508705	ENSP00000423174
ENST00000528793	ENSP00000433511

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.

Experimentally validated
Total	21 [view]
Protein-Protein	20 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004703	G-protein coupled receptor kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0016055	Wnt signaling pathway
GO:0038032	termination of G-protein coupled receptor signaling pathway

Cellular Component

GO:0016020

membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000074886

View Gene Order

ENSBTAG00000043994

Not yet available

Pathways

NETPATH

NetPath_25

FSH pathway

REACTOME

KEGG

hsa04144

Endocytosis pathway

hsa04062

Chemokine signaling pathway pathway

INOH

INOH website

IL-7 signaling pathway

INOH website

JAK STAT pathway and regulation pathway

INOH website

EPO signaling pathway pathway

INOH website

VEGF signaling pathway pathway

PID NCI

cxcr4_pathway

CXCR4-mediated signaling events

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.235116 Hs.609613

RefSeq

NM_001004105 NM_001004106 NM_002082 XM_006714858 XM_006714859 XM_006714860

HUGO

OMIM

CCDS

CCDS34303 CCDS43406 CCDS47348

HPRD

02925

IMGT

EMBL

GenPept

RNA Seq Atlas