Homo sapiens Gene: GRK6
Summary
InnateDB Gene IDBG-60027.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GRK6
Gene Name G protein-coupled receptor kinase 6
Synonyms GPRK6;
Species Homo sapiens
Ensembl Gene ENSG00000198055
Encoded Proteins
G protein-coupled receptor kinase 6
G protein-coupled receptor kinase 6
G protein-coupled receptor kinase 6
G protein-coupled receptor kinase 6
G protein-coupled receptor kinase 6
G protein-coupled receptor kinase 6
G protein-coupled receptor kinase 6
G protein-coupled receptor kinase 6
G protein-coupled receptor kinase 6
G protein-coupled receptor kinase 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:177403204-177442901
Strand Forward strand
Band q35.3
Transcripts
ENST00000355472 ENSP00000347655
ENST00000355958 ENSP00000348230
ENST00000393576 ENSP00000377204
ENST00000502598 ENSP00000422873
ENST00000506296 ENSP00000421055
ENST00000511244 ENSP00000425391
ENST00000507633 ENSP00000427581
ENST00000512684 ENSP00000422342
ENST00000515666
ENST00000508705 ENSP00000423174
ENST00000528793 ENSP00000433511
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated
Total 21 [view]
Protein-Protein 20 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004703 G-protein coupled receptor kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0016055 Wnt signaling pathway
GO:0038032 termination of G-protein coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
FSH pathway
REACTOME
KEGG
Chemokine signaling pathway pathway
Endocytosis pathway
INOH
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
PID BIOCARTA
PID NCI
CXCR4-mediated signaling events
Cross-References
SwissProt P43250
TrEMBL D6R9V4 D6RDA3 D6RHC7
UniProt Splice Variant
Entrez Gene 2870
UniGene Hs.235116 Hs.609613
RefSeq NM_001004106 NM_001004105 NM_002082 XM_006714860 XM_006714859 XM_006714858
HUGO HGNC:4545
OMIM 600869
CCDS CCDS34303 CCDS43406 CCDS47348
HPRD 02925
IMGT
EMBL AC145098 AF040751 AF040752 BC009277 L16862 U00686
GenPept AAA03565 AAA60175 AAC09273 AAC09274 AAH09277
RNA Seq Atlas 2870