Version 5.4
Mus musculus Gene: Ccbl1
Summary
InnateDB Gene IDBG-155774.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ccbl1
Gene Name cysteine conjugate-beta lyase 1
Synonyms 2010009K05Rik; AI182306; Gtk; Kat1; KatI
Species Mus musculus
Ensembl Gene ENSMUSG00000039648
Encoded Proteins
IDBP-155776
cysteine conjugate-beta lyase 1
IDBP-253402
cysteine conjugate-beta lyase 1
IDBP-253404
cysteine conjugate-beta lyase 1
IDBP-253406
cysteine conjugate-beta lyase 1
IDBP-253408
cysteine conjugate-beta lyase 1
IDBP-253410
cysteine conjugate-beta lyase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171097:
This gene encodes a cytosolic enzyme that is responsible for the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes. This metabolism can form reactive metabolites leading to nephrotoxicity and neurotoxicity. Increased levels of this enzyme have been linked to schizophrenia. Multiple transcript variants that encode different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:30185124-30205847
Strand Reverse strand
Band B
Transcripts
ENSMUST00000044038 ENSMUSP00000038612
ENSMUST00000113663 ENSMUSP00000109293
ENSMUST00000113662 ENSMUSP00000109292
ENSMUST00000113661 ENSMUSP00000109291
ENSMUST00000113660 ENSMUSP00000109290
ENSMUST00000113659 ENSMUSP00000109289
ENSMUST00000148555
ENSMUST00000149522
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0016212 kynurenine-oxoglutarate transaminase activity
GO:0030170 pyridoxal phosphate binding
GO:0042803 protein homodimerization activity
GO:0047312 L-phenylalanine:pyruvate aminotransferase activity
GO:0047316 glutamine-phenylpyruvate transaminase activity
GO:0047804 cysteine-S-conjugate beta-lyase activity
GO:0047945 L-glutamine:pyruvate aminotransferase activity
Biological Process
GO:0009058 biosynthetic process
GO:0070189 kynurenine metabolic process
GO:0097053 L-kynurenine catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000171097
View Gene Order
ENSBTAG00000036101
Not yet available
Pathways
NETPATH
REACTOME
REACT_189085
Disease pathway
REACT_261966
Phenylalanine and tyrosine catabolism pathway
REACT_188937
Metabolism pathway
REACT_232845
Metabolism of amino acids and derivatives pathway
REACT_240936
Tryptophan catabolism pathway
REACT_189094
Abnormal metabolism in phenylketonuria pathway
REACT_239550
Amino acid synthesis and interconversion (transamination) pathway
KEGG
mmu00380
Tryptophan metabolism pathway
mmu00450
Selenocompound metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_916
Tryptophan catabolism pathway
REACT_238
Amino acid synthesis and interconversion (transamination) pathway
REACT_1786
Phenylalanine and tyrosine catabolism pathway
REACT_121117
Abnormal metabolism in phenylketonuria pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
REACT_116125
Disease pathway
KEGG
hsa00380
Tryptophan metabolism pathway
hsa00450
Selenocompound metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL A2AQY8
UniProt Splice Variant
Entrez Gene 70266
UniGene
RefSeq NM_172404 XM_006498314
OMIM
CCDS CCDS15874
HPRD
IMGT
MGI ID MGI:1917516
MGI Symbol Ccbl1
EMBL AL845258
GenPept
RNA Seq Atlas 70266

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca