Mus musculus Gene: Lrrc8a
InnateDB Gene IDBG-155882.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lrrc8a
Gene Name leucine rich repeat containing 8A
Species Mus musculus
Ensembl Gene ENSMUSG00000007476
Encoded Proteins
leucine rich repeat containing 8A
leucine rich repeat containing 8A
predicted gene, 28035
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136802:
This gene encodes a protein belonging to the leucine-rich repeat family of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions. This family member is a putative four-pass transmembrane protein that plays a role in B cell development. Defects in this gene cause autosomal dominant non-Bruton type agammaglobulinemia, an immunodeficiency disease resulting from defects in B cell maturation. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:30237715-30263790
Strand Forward strand
Band B
ENSMUST00000095078 ENSMUSP00000092690
ENSMUST00000113654 ENSMUSP00000109284
ENSMUST00000139454 ENSMUSP00000139038
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0002329 pre-B cell differentiation
GO:0006820 anion transport
GO:0006884 cell volume homeostasis
GO:0006970 response to osmotic stress
Cellular Component
GO:0005886 plasma membrane
GO:0034702 ion channel complex
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
SwissProt Q80WG5
UniProt Splice Variant
Entrez Gene 241296
UniGene Mm.389232 Mm.475219
RefSeq NM_177725
MGI ID MGI:2652847
MGI Symbol Lrrc8a
EMBL AL845258 BC048152 CH466542
GenPept CAM20568 EDL08450
RNA Seq Atlas 241296