Version 5.4
| Mus musculus Protein: Lrrc8a | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-155886.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Lrrc8a | ||||||||
| Protein Name | leucine rich repeat containing 8A | ||||||||
| Synonyms | |||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000092690 | ||||||||
| InnateDB Gene | IDBG-155882 (Lrrc8a) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. It is unclear whether LRRC8A constitutes a pore-forming subunit or whether it is closely associated with the pore and mediates channel properties such as ion selectivity (By similarity). Involved in B-cell development: required for the pro- B cell to pre-B cell transition. Also required for T-cell development. {ECO:0000250, ECO:0000269PubMed:14660746, ECO:0000269PubMed:24752297}. | ||||||||
| Subcellular Localization | Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Ubiquitously expressed. High levels detected in the bone marrow; lower levels found in peripheral blood cells. {ECO:0000269PubMed:14660746, ECO:0000269PubMed:15094057, ECO:0000269PubMed:24725410, ECO:0000269PubMed:24752297}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:2652847 | ||||||||
| InterPro |
IPR001611
Leucine-rich repeat IPR003591 Leucine-rich repeat, typical subtype IPR021040 Leucine-rich repeat-containing protein 8, N-terminal |
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| PFAM |
PF00560
PF13504 PF13855 PF12534 |
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| PRINTS | |||||||||
| PIRSF | |||||||||
| SMART |
SM00369
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q80WG5 | ||||||||
| PhosphoSite | PhosphoSite-Q80WG5 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 241296 | ||||||||
| UniGene | Mm.475219 | ||||||||
| RefSeq | NP_808393 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Lrrc8a | ||||||||
| OMIM | |||||||||
| CCDS | CCDS15875 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AL845258 BC048152 CH466542 | ||||||||
| GenPept | CAM20568 EDL08450 | ||||||||