Homo sapiens Gene: SERPINF1
Summary
InnateDB Gene IDBG-15621.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SERPINF1
Gene Name serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
Synonyms EPC-1; OI12; OI6; PEDF;
Species Homo sapiens
Ensembl Gene ENSG00000132386
Encoded Proteins
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the serpin family, although it does not display the serine protease inhibitory activity shown by many of the other serpin family members. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells.[provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:1761959-1777574
Strand Forward strand
Band p13.3
Transcripts
ENST00000254722 ENSP00000254722
ENST00000577053 ENSP00000460842
ENST00000576406 ENSP00000461214
ENST00000572517
ENST00000571149 ENSP00000460905
ENST00000571870
ENST00000570731 ENSP00000459869
ENST00000572048 ENSP00000458484
ENST00000573770 ENSP00000459107
ENST00000571360 ENSP00000461660
ENST00000570820
ENST00000573763 ENSP00000461405
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 6 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
Biological Process
GO:0001822 kidney development
GO:0007275 multicellular organismal development
GO:0007568 aging
GO:0007614 short-term memory
GO:0008283 cell proliferation
GO:0010447 response to acidity
GO:0010596 negative regulation of endothelial cell migration
GO:0010629 negative regulation of gene expression
GO:0010951 negative regulation of endopeptidase activity
GO:0010976 positive regulation of neuron projection development
GO:0016525 negative regulation of angiogenesis
GO:0030162 regulation of proteolysis
GO:0042698 ovulation cycle
GO:0046685 response to arsenic-containing substance
GO:0050728 negative regulation of inflammatory response
GO:0050769 positive regulation of neurogenesis
GO:0060041 retina development in camera-type eye
GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0071279 cellular response to cobalt ion
GO:0071300 cellular response to retinoic acid
GO:0071333 cellular response to glucose stimulus
GO:0071549 cellular response to dexamethasone stimulus
GO:1901215 negative regulation of neuron death
Cellular Component
GO:0005576 extracellular region
GO:0005604 basement membrane
GO:0005615 extracellular space
GO:0030424 axon
GO:0031012 extracellular matrix
GO:0042470 melanosome
GO:0043025 neuronal cell body
GO:0043203 axon hillock
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL I3L425
UniProt Splice Variant
Entrez Gene 5176
UniGene
RefSeq NM_002615
HUGO HGNC:8824
OMIM 172860
CCDS CCDS11012
HPRD 01408
IMGT
EMBL AC130343 AC130689
GenPept
RNA Seq Atlas 102723646 5176