InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Serpinf1

Summary

InnateDB Gene

IDBG-199867.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Serpinf1

Gene Name

serine (or cysteine) peptidase inhibitor, clade F, member 1

Synonyms

AI195227; EPC-1; Pedf; Pedfl; Sdf3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000000753

Encoded Proteins

IDBP-199869

serine (or cysteine) peptidase inhibitor, clade F, member 1

IDBP-539966

serine (or cysteine) peptidase inhibitor, clade F, member 1

IDBP-538061

serine (or cysteine) peptidase inhibitor, clade F, member 1

IDBP-627745

serine (or cysteine) peptidase inhibitor, clade F, member 1

IDBP-627747

serine (or cysteine) peptidase inhibitor, clade F, member 1

IDBP-627739

serine (or cysteine) peptidase inhibitor, clade F, member 1

IDBP-627740

serine (or cysteine) peptidase inhibitor, clade F, member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132386:
The protein encoded by this gene is a member of the serpin family, although it does not display the serine protease inhibitory activity shown by many of the other serpin family members. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells.[provided by RefSeq, Mar 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:75409769-75422701

Strand

Reverse strand

Band

Transcripts

ENSMUST00000000769	ENSMUSP00000000769
ENSMUST00000138661	ENSMUSP00000121180
ENSMUST00000139403
ENSMUST00000137103	ENSMUSP00000114761
ENSMUST00000125982	ENSMUSP00000126807
ENSMUST00000155009	ENSMUSP00000131531
ENSMUST00000168902	ENSMUSP00000131043
ENSMUST00000167281	ENSMUSP00000133230

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004867	serine-type endopeptidase inhibitor activity

Biological Process

GO:0001822	kidney development
GO:0007568	aging
GO:0007614	short-term memory
GO:0010447	response to acidity
GO:0010596	negative regulation of endothelial cell migration
GO:0010629	negative regulation of gene expression
GO:0010951	negative regulation of endopeptidase activity
GO:0010976	positive regulation of neuron projection development
GO:0016525	negative regulation of angiogenesis
GO:0030162	regulation of proteolysis
GO:0032526	response to retinoic acid
GO:0042698	ovulation cycle
GO:0046685	response to arsenic-containing substance
GO:0050728	negative regulation of inflammatory response
GO:0050769	positive regulation of neurogenesis
GO:0051384	response to glucocorticoid
GO:0060041	retina development in camera-type eye
GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0071279	cellular response to cobalt ion
GO:0071300	cellular response to retinoic acid
GO:0071333	cellular response to glucose stimulus
GO:0071549	cellular response to dexamethasone stimulus
GO:1901215	negative regulation of neuron death

Cellular Component

GO:0005576	extracellular region
GO:0005604	basement membrane
GO:0005615	extracellular space
GO:0030424	axon
GO:0031012	extracellular matrix
GO:0042470	melanosome
GO:0043025	neuronal cell body
GO:0043203	axon hillock
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000132386

View Gene Order

ENSBTAG00000009705

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.2044

RefSeq

NM_011340

OMIM

CCDS

CCDS25045

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas