InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RAMP3

Summary

InnateDB Gene

IDBG-15634.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAMP3

Gene Name

receptor (G protein-coupled) activity modifying protein 3

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000122679

Encoded Proteins

IDBP-15636

receptor (G protein-coupled) activity modifying protein 3

IDBP-484833

receptor (G protein-coupled) activity modifying protein 3

IDBP-477533

receptor (G protein-coupled) activity modifying protein 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:45157791-45186302

Strand

Forward strand

Band

p13

Transcripts

ENST00000242249	ENSP00000242249
ENST00000481345	ENSP00000419012
ENST00000496212	ENSP00000418460

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0008565	protein transporter activity
GO:0015026	coreceptor activity

Biological Process

GO:0001921	positive regulation of receptor recycling
GO:0006816	calcium ion transport
GO:0006886	intracellular protein transport
GO:0007186	G-protein coupled receptor signaling pathway
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0015031	protein transport
GO:0031623	receptor internalization
GO:0045892	negative regulation of transcription, DNA-templated
GO:0071392	cellular response to estradiol stimulus
GO:0072659	protein localization to plasma membrane
GO:0086103	G-protein coupled receptor signaling pathway involved in heart process
GO:0090004	positive regulation of establishment of protein localization to plasma membrane

Cellular Component

GO:0005622	intracellular
GO:0005764	lysosome
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0043235	receptor complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000041046

View Gene Order

ENSBTAG00000020704

Not yet available

Pathways

NETPATH

REACTOME

REACT_19327

G alpha (s) signalling events pathway

REACT_18290

Calcitonin-like ligand receptors pathway

REACT_18372

Class B/2 (Secretin family receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_21340

GPCR ligand binding pathway

KEGG

hsa04270

Vascular smooth muscle contraction pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_005856 XM_006715631 XM_006715632

HUGO

OMIM

CCDS

CCDS5503

HPRD

05517

IMGT

EMBL

GenPept

RNA Seq Atlas