Homo sapiens Gene: RAMP3
Summary
InnateDB Gene IDBG-15634.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAMP3
Gene Name receptor (G protein-coupled) activity modifying protein 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000122679
Encoded Proteins
receptor (G protein-coupled) activity modifying protein 3
receptor (G protein-coupled) activity modifying protein 3
receptor (G protein-coupled) activity modifying protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:45157791-45186302
Strand Forward strand
Band p13
Transcripts
ENST00000242249 ENSP00000242249
ENST00000481345 ENSP00000419012
ENST00000496212 ENSP00000418460
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0008565 protein transporter activity
GO:0015026 coreceptor activity
Biological Process
GO:0001921 positive regulation of receptor recycling
GO:0006816 calcium ion transport
GO:0006886 intracellular protein transport
GO:0007186 G-protein coupled receptor signaling pathway
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0015031 protein transport
GO:0031623 receptor internalization
GO:0045892 negative regulation of transcription, DNA-templated
GO:0071392 cellular response to estradiol stimulus
GO:0072659 protein localization to plasma membrane
GO:0086103 G-protein coupled receptor signaling pathway involved in heart process
GO:0090004 positive regulation of establishment of protein localization to plasma membrane
Cellular Component
GO:0005622 intracellular
GO:0005764 lysosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0043235 receptor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
G alpha (s) signalling events pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Calcitonin-like ligand receptors pathway
GPCR ligand binding pathway
Class B/2 (Secretin family receptors) pathway
KEGG
Vascular smooth muscle contraction pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O60896
TrEMBL A4D2L1 M5AMS3
UniProt Splice Variant
Entrez Gene 10268
UniGene
RefSeq NM_005856 XM_006715631 XM_006715632
HUGO HGNC:9845
OMIM 605155
CCDS CCDS5503
HPRD 05517
IMGT
EMBL AB291071 AC004844 AJ001016 AK311871 AY265459 BC022304 BC053852 CH236960 CH471128
GenPept AAH22304 AAH53852 AAP23300 BAG34812 BAN10198 CAA04474 EAL23743 EAW61048
RNA Seq Atlas 10268