InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RAMP3

Summary

InnateDB Protein

IDBP-484833.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAMP3

Protein Name

receptor (G protein-coupled) activity modifying protein 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000419012

InnateDB Gene

IDBG-15634 (RAMP3)

Protein Structure

UniProt Annotation

Function

Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL. {ECO:0000269PubMed:23674134, ECO:0000269PubMed:9620797}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:23674134}; Single-pass type I membrane protein {ECO:0000269PubMed:23674134}. Membrane {ECO:0000269PubMed:23674134}; Single-pass type I membrane protein {ECO:0000269PubMed:23674134}. Note=Moves from intracellular puncta to the plasma membrane in a RAMP3-dependent manner.

Disease Associations

Tissue Specificity

Strongly expressed in lung, breast, immune system and fetal tissues. {ECO:0000269PubMed:9620797}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0008565	protein transporter activity

Biological Process

GO:0001921	positive regulation of receptor recycling
GO:0006816	calcium ion transport
GO:0006886	intracellular protein transport
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0015031	protein transport
GO:0031623	receptor internalization
GO:0045892	negative regulation of transcription, DNA-templated
GO:0071392	cellular response to estradiol stimulus
GO:0072659	protein localization to plasma membrane
GO:0086103	G-protein coupled receptor signaling pathway involved in heart process
GO:0090004	positive regulation of establishment of protein localization to plasma membrane

Cellular Component

GO:0005622	intracellular
GO:0005764	lysosome
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0043235	receptor complex