|Homo sapiens Gene: SIRT3|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||sirtuin 3|
|Useful resources||Stemformatics EHFPI ImmGen|
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene. [provided by RefSeq, Jul 2008]
|Genomic Location||Chromosome 11:215458-236931|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 100 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Possible paralog/unusual divergence/ gene prediction error
Organelle biogenesis and maintenance pathway
Mitochondrial biogenesis pathway
Transcriptional activation of mitochondrial biogenesis pathway
Signaling events mediated by HDAC Class III
|UniProt Splice Variant|
|RNA Seq Atlas||23410|