Version 5.4
Bos taurus Gene: SIRT3
Summary
InnateDB Gene IDBG-641924.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SIRT3
Gene Name NAD-dependent deacetylase sirtuin-3, mitochondrial
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000002044
Encoded Proteins
IDBP-694349
sirtuin 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000142082:
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:107167131-107189741
Strand Reverse strand
Band
Transcripts
ENSBTAT00000002648 ENSBTAP00000002648
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 91 interaction(s) predicted by orthology.
Predicted by orthology
Total 91 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0051287 NAD binding
GO:0070403 NAD+ binding
Biological Process
GO:0006476 protein deacetylation
GO:0009060 aerobic respiration
GO:0034983 peptidyl-lysine deacetylation
GO:0070932 histone H3 deacetylation
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000142082
View Gene Order
ENSMUSG00000025486
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_200751
Organelle biogenesis and maintenance pathway
REACT_200788
Mitochondrial biogenesis pathway
REACT_200608
Transcriptional activation of mitochondrial biogenesis pathway
KEGG
INOH
PID NCI
hdac_classiii_pathway
Signaling events mediated by HDAC Class III
Cross-References
SwissProt
TrEMBL G5E521
UniProt Splice Variant
Entrez Gene 614027
UniGene Bt.56046
RefSeq NM_001206669 XM_005200934
HUGO HGNC:14931
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02032476
GenPept
RNA Seq Atlas 614027

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca