Version 5.4
Mus musculus Gene: Caml
Summary
InnateDB Gene IDBG-156532.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Caml
Gene Name calcium modulating ligand
Synonyms AI385748; Camlg
Species Mus musculus
Ensembl Gene ENSMUSG00000021501
Encoded Proteins
IDBP-156534
calcium modulating ligand
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164615:
The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:55623005-55632411
Strand Forward strand
Band B1
Transcripts
ENSMUST00000021963 ENSMUSP00000021963
ENSMUST00000169228
ENSMUST00000165154
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0050839 cell adhesion molecule binding
Biological Process
GO:0001881 receptor recycling
GO:0007173 epidermal growth factor receptor signaling pathway
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000164615
View Gene Order
ENSBTAG00000021519
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_56
Prolactin pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt P49070
TrEMBL Q6P3A5
UniProt Splice Variant
Entrez Gene 12328
UniGene Mm.2313 Mm.397673
RefSeq NM_007596
OMIM
CCDS CCDS26551
HPRD
IMGT
MGI ID MGI:104728
MGI Symbol Caml
EMBL AF078112 BC005688 BC064104 U21960
GenPept AAA87004 AAC33940 AAH05688 AAH64104
RNA Seq Atlas 12328

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca