Version 5.4
Homo sapiens Gene: CAMLG
Summary
InnateDB Gene IDBG-45075.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CAMLG
Gene Name calcium modulating ligand
Synonyms CAML
Species Homo sapiens
Ensembl Gene ENSG00000164615
Encoded Proteins
IDBP-45077
calcium modulating ligand
IDBP-480413
calcium modulating ligand
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:134738501-134752160
Strand Forward strand
Band q31.1
Transcripts
ENST00000297156 ENSP00000297156
ENST00000514518 ENSP00000427331
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 12 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0050839 cell adhesion molecule binding
Biological Process
GO:0001881 receptor recycling
GO:0006952 defense response
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0016032 viral process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021501
View Gene Order
ENSBTAG00000021519
Not yet available
Pathways
NETPATH
NetPath_56
Prolactin pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt P49069
TrEMBL D6RIW3
UniProt Splice Variant
Entrez Gene 819
UniGene Hs.529846 Hs.600007
RefSeq NM_001745
HUGO HGNC:1471
OMIM 601118
CCDS CCDS4178
HPRD
IMGT
EMBL AC010301 AF068179 AK313156 BC130325 CH471062 U18242
GenPept AAA59420 AAC23596 AAI30326 BAG35974 EAW62243 EAW62244
RNA Seq Atlas 819

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca