Homo sapiens Gene: ADCY1
InnateDB Gene IDBG-15668.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADCY1
Gene Name adenylate cyclase 1 (brain)
Synonyms AC1; DFNB44
Species Homo sapiens
Ensembl Gene ENSG00000164742
Encoded Proteins
adenylate cyclase 1 (brain)
adenylate cyclase 1 (brain)
adenylate cyclase 1 (brain)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a form of adenylate cyclase expressed in brain. A similar protein in mouse is involved in pattern formation of the brain. [provided by RefSeq, Jul 2008]
This gene encodes a member of the of adenylate cyclase gene family that is primarily expressed in the brain. This protein is regulated by calcium/calmodulin concentration and may be involved in brain development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:45574140-45723116
Strand Forward strand
Band p12.3
ENST00000297323 ENSP00000297323
ENST00000432715 ENSP00000392721
ENST00000621543 ENSP00000479770
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004016 adenylate cyclase activity
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity
GO:0016849 phosphorus-oxygen lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0006112 energy reserve metabolic process
GO:0006171 cAMP biosynthetic process
GO:0006833 water transport
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007268 synaptic transmission
GO:0007409 axonogenesis
GO:0007616 long-term memory
GO:0007623 circadian rhythm
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009190 cyclic nucleotide biosynthetic process
GO:0010226 response to lithium ion
GO:0034199 activation of protein kinase A activity
GO:0035556 intracellular signal transduction
GO:0042493 response to drug
GO:0042752 regulation of circadian rhythm
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0055085 transmembrane transport
GO:0071377 cellular response to glucagon stimulus
Cellular Component
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
PKA activation pathway
PKA-mediated phosphorylation of CREB pathway
Calmodulin induced events pathway
CaM pathway pathway
DAG and IP3 signaling pathway
DAP12 signaling pathway
DAP12 interactions pathway
Vasopressin regulates renal water homeostasis via Aquaporins pathway
PLC-gamma1 signalling pathway
EGFR interacts with phospholipase C-gamma pathway
Signaling by EGFR pathway
G alpha (i) signalling events pathway
G alpha (s) signalling events pathway
G alpha (z) signalling events pathway
Adenylate cyclase activating pathway pathway
Adenylate cyclase inhibitory pathway pathway
PLC beta mediated events pathway
Opioid Signalling pathway
PLCG1 events in ERBB2 signaling pathway
Signaling by ERBB2 pathway
Phospholipase C-mediated cascade pathway
Signaling by FGFR pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
GABA B receptor activation pathway
PKA activation in glucagon signalling pathway
Glucagon signaling in metabolic regulation pathway
Integration of energy metabolism pathway
CREB phosphorylation through the activation of Adenylate Cyclase pathway
Signaling by FGFR in disease pathway
Transmembrane transport of small molecules pathway
Signalling by NGF pathway
Signaling by Hedgehog pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Neuronal System pathway
Signaling by GPCR pathway
Innate Immune System pathway
GABA receptor activation pathway
Activation of GABAB receptors pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Hedgehog 'off' state pathway
Post NMDA receptor activation events pathway
G-protein mediated events pathway
Immune System pathway
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
NGF signalling via TRKA from the plasma membrane pathway
Transmission across Chemical Synapses pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Metabolism pathway
Inhibition of adenylate cyclase pathway pathway
Ca-dependent events pathway
Aquaporin-mediated transport pathway
Disease pathway
GnRH signaling pathway pathway
Gap junction pathway
Purine metabolism pathway
Long-term potentiation pathway
Calcium signaling pathway pathway
Melanogenesis pathway
Vascular smooth muscle contraction pathway
Chemokine signaling pathway pathway
Progesterone-mediated oocyte maturation pathway
Dilated cardiomyopathy pathway
Oocyte meiosis pathway
Gastric acid secretion pathway
Amoebiasis pathway
Chagas disease (American trypanosomiasis) pathway
Pancreatic secretion pathway
Salivary secretion pathway
Bile secretion pathway
GPCR Adenosine A2A receptor signaling pathway pathway
Purine nucleotides nucleosides metabolism pathway
GPCR signaling pathway
UniProt Splice Variant
Entrez Gene
UniGene Hs.192215
RefSeq NM_001281768 NM_021116 XM_005249584 XM_005249585
CCDS CCDS34631 CCDS75593
HPRD 00053
RNA Seq Atlas