InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADCY1

Summary

InnateDB Protein

IDBP-15670.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADCY1

Protein Name

adenylate cyclase 1 (brain)

Synonyms

AC1; DFNB44;

Species

Homo sapiens

Ensembl Protein

ENSP00000297323

InnateDB Gene

IDBG-15668 (ADCY1)

Protein Structure

UniProt Annotation

Function

This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Brain, retina and adrenal medulla.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004016	adenylate cyclase activity
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity
GO:0016849	phosphorus-oxygen lyase activity
GO:0046872	metal ion binding

Biological Process

GO:0006112	energy reserve metabolic process
GO:0006171	cAMP biosynthetic process
GO:0006833	water transport
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007202	activation of phospholipase C activity
GO:0007268	synaptic transmission
GO:0007409	axonogenesis
GO:0007616	long-term memory
GO:0007623	circadian rhythm
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0009190	cyclic nucleotide biosynthetic process
GO:0010226	response to lithium ion
GO:0034199	activation of protein kinase A activity
GO:0035556	intracellular signal transduction
GO:0042493	response to drug
GO:0042752	regulation of circadian rhythm
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0055085	transmembrane transport
GO:0071377	cellular response to glucagon stimulus