InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Aldh6a1

Summary

InnateDB Gene

IDBG-156754.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aldh6a1

Gene Name

aldehyde dehydrogenase family 6, subfamily A1

Synonyms

1110038I05Rik; AI314632; Mmsdh

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021238

Encoded Proteins

IDBP-156756

aldehyde dehydrogenase family 6, subfamily A1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000119711:
This protein belongs to the aldehyde dehydrogenases family of proteins. This enzyme plays a role in the valine and pyrimidine catabolic pathways. The product of this gene, a mitochondrial methylmalonate semialdehyde dehydrogenase, catalyzes the irreversible oxidative decarboxylation of malonate and methylmalonate semialdehydes to acetyl- and propionyl-CoA. Methylmalonate semialdehyde dehydrogenase deficiency is characterized by elevated beta-alanine, 3-hydroxypropionic acid, and both isomers of 3-amino and 3-hydroxyisobutyric acids in urine organic acids. [provided by RefSeq, Jul 2008]
This gene encodes a member of the aldehyde dehydrogenase protein family. The encoded protein is a mitochondrial methylmalonate semialdehyde dehydrogenase that plays a role in the valine and pyrimidine catabolic pathways. This protein catalyzes the irreversible oxidative decarboxylation of malonate and methylmalonate semialdehydes to acetyl- and propionyl-CoA. Methylmalonate semialdehyde dehydrogenase deficiency is characterized by elevated beta-alanine, 3-hydroxypropionic acid, and both isomers of 3-amino and 3-hydroxyisobutyric acids in urine organic acids. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:84430723-84450950

Strand

Reverse strand

Band

Transcripts

ENSMUST00000085192

ENSMUSP00000082288

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004491	methylmalonate-semialdehyde dehydrogenase (acylating) activity
GO:0016491	oxidoreductase activity
GO:0018478	malonate-semialdehyde dehydrogenase (acetylating) activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006210	thymine catabolic process
GO:0006574	valine catabolic process
GO:0008152	metabolic process
GO:0050873	brown fat cell differentiation
GO:0055114	oxidation-reduction process