InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.98765

Summary

InnateDB Gene

IDBG-646848.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.98765

Gene Name

methylmalonate-semialdehyde dehydrogenase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000018469

Encoded Proteins

IDBP-699687

methylmalonate-semialdehyde dehydrogenase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000119711:
This protein belongs to the aldehyde dehydrogenases family of proteins. This enzyme plays a role in the valine and pyrimidine catabolic pathways. The product of this gene, a mitochondrial methylmalonate semialdehyde dehydrogenase, catalyzes the irreversible oxidative decarboxylation of malonate and methylmalonate semialdehydes to acetyl- and propionyl-CoA. Methylmalonate semialdehyde dehydrogenase deficiency is characterized by elevated beta-alanine, 3-hydroxypropionic acid, and both isomers of 3-amino and 3-hydroxyisobutyric acids in urine organic acids. [provided by RefSeq, Jul 2008]
This gene encodes a member of the aldehyde dehydrogenase protein family. The encoded protein is a mitochondrial methylmalonate semialdehyde dehydrogenase that plays a role in the valine and pyrimidine catabolic pathways. This protein catalyzes the irreversible oxidative decarboxylation of malonate and methylmalonate semialdehydes to acetyl- and propionyl-CoA. Methylmalonate semialdehyde dehydrogenase deficiency is characterized by elevated beta-alanine, 3-hydroxypropionic acid, and both isomers of 3-amino and 3-hydroxyisobutyric acids in urine organic acids. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:85821883-85839587

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000024584

ENSBTAP00000024584

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004491	methylmalonate-semialdehyde dehydrogenase (acylating) activity
GO:0016491	oxidoreductase activity
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006210	thymine catabolic process
GO:0006574	valine catabolic process
GO:0008152	metabolic process
GO:0050873	brown fat cell differentiation
GO:0055114	oxidation-reduction process