Version 5.4
Mus musculus Gene: Nek1
Summary
InnateDB Gene IDBG-156801.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nek1
Gene Name NIMA (never in mitosis gene a)-related expressed kinase 1
Synonyms D8Ertd790e; kat
Species Mus musculus
Ensembl Gene ENSMUSG00000031644
Encoded Proteins
IDBP-156805
NIMA (never in mitosis gene a)-related expressed kinase 1
IDBP-401266
NIMA (never in mitosis gene a)-related expressed kinase 1
IDBP-532332
NIMA (never in mitosis gene a)-related expressed kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137601:
The protein encoded by this gene is a serine/threonine kinase involved in cell cycle regulation. The encoded protein is found in a centrosomal complex with FEZ1, a neuronal protein that plays a role in axonal development. Defects in this gene are a cause of polycystic kidney disease (PKD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:60993195-61131346
Strand Forward strand
Band B3.1
Transcripts
ENSMUST00000034065 ENSMUSP00000034065
ENSMUST00000120689 ENSMUSP00000113932
ENSMUST00000125717
ENSMUST00000155664
ENSMUST00000140444
ENSMUST00000154313
ENSMUST00000142601 ENSMUSP00000121479
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0046872 metal ion binding
Biological Process
GO:0006468 protein phosphorylation
GO:0006974 cellular response to DNA damage stimulus
GO:0007067 mitotic nuclear division
GO:0010212 response to ionizing radiation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0042384 cilium assembly
Cellular Component
GO:0000242 pericentriolar material
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0031965 nuclear membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000137601
View Gene Order
ENSBTAG00000026915
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_175089 XM_006509295
OMIM
CCDS CCDS40347
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca