Mus musculus Gene: Cdk5rap2
Summary
InnateDB Gene IDBG-156923.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cdk5rap2
Gene Name CDK5 regulatory subunit associated protein 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000039298
Encoded Proteins
CDK5 regulatory subunit associated protein 2
CDK5 regulatory subunit associated protein 2
CDK5 regulatory subunit associated protein 2
CDK5 regulatory subunit associated protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136861:
This gene encodes a regulator of CDK5 (cyclin-dependent kinase 5) activity. The protein encoded by this gene is localized to the centrosome and Golgi complex, interacts with CDK5R1 and pericentrin (PCNT), plays a role in centriole engagement and microtubule nucleation, and has been linked to primary microcephaly and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:70216856-70410443
Strand Reverse strand
Band C2
Transcripts
ENSMUST00000076541 ENSMUSP00000075856
ENSMUST00000144099 ENSMUSP00000119891
ENSMUST00000138561 ENSMUSP00000116928
ENSMUST00000124251
ENSMUST00000140108 ENSMUSP00000119151
ENSMUST00000126416
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0008017 microtubule binding
GO:0015631 tubulin binding
GO:0019901 protein kinase binding
GO:0032403 protein complex binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0000132 establishment of mitotic spindle orientation
GO:0000226 microtubule cytoskeleton organization
GO:0001578 microtubule bundle formation
GO:0007059 chromosome segregation
GO:0007420 brain development
GO:0022008 neurogenesis
GO:0045665 negative regulation of neuron differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046600 negative regulation of centriole replication
GO:0051297 centrosome organization
GO:0090231 regulation of spindle checkpoint
Cellular Component
GO:0000242 pericentriolar material
GO:0000922 spindle pole
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005813 centrosome
GO:0005874 microtubule
GO:0030054 cell junction
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Recruitment of mitotic centrosome proteins and complexes pathway
G2/M Transition pathway
Cell Cycle, Mitotic pathway
Loss of Nlp from mitotic centrosomes pathway
Cell Cycle pathway
Mitotic G2-G2/M phases pathway
Loss of proteins required for interphase microtubule organization√?¬†from the centrosome pathway
Regulation of PLK1 Activity at G2/M Transition pathway
Centrosome maturation pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Regulation of PLK1 Activity at G2/M Transition pathway
Loss of Nlp from mitotic centrosomes pathway
Loss of proteins required for interphase microtubule organization√?¬†from the centrosome pathway
Recruitment of mitotic centrosome proteins and complexes pathway
Cell Cycle pathway
Centrosome maturation pathway
G2/M Transition pathway
Cell Cycle, Mitotic pathway
Mitotic G2-G2/M phases pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.370777 Mm.379344
RefSeq NM_145990 XM_006537746 XM_006537750
OMIM
CCDS CCDS38779
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas