InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cdk5rap2

Summary

InnateDB Gene

IDBG-156923.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdk5rap2

Gene Name

CDK5 regulatory subunit associated protein 2

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000039298

Encoded Proteins

IDBP-156927

CDK5 regulatory subunit associated protein 2

IDBP-531527

CDK5 regulatory subunit associated protein 2

IDBP-541931

CDK5 regulatory subunit associated protein 2

IDBP-540233

CDK5 regulatory subunit associated protein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136861:
This gene encodes a regulator of CDK5 (cyclin-dependent kinase 5) activity. The protein encoded by this gene is localized to the centrosome and Golgi complex, interacts with CDK5R1 and pericentrin (PCNT), plays a role in centriole engagement and microtubule nucleation, and has been linked to primary microcephaly and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:70216856-70410443

Strand

Reverse strand

Band

Transcripts

ENSMUST00000076541	ENSMUSP00000075856
ENSMUST00000144099	ENSMUSP00000119891
ENSMUST00000138561	ENSMUSP00000116928
ENSMUST00000124251
ENSMUST00000140108	ENSMUSP00000119151
ENSMUST00000126416

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0008017	microtubule binding
GO:0015631	tubulin binding
GO:0019901	protein kinase binding
GO:0032403	protein complex binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0000132	establishment of mitotic spindle orientation
GO:0000226	microtubule cytoskeleton organization
GO:0001578	microtubule bundle formation
GO:0007059	chromosome segregation
GO:0007420	brain development
GO:0022008	neurogenesis
GO:0045665	negative regulation of neuron differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046600	negative regulation of centriole replication
GO:0051297	centrosome organization
GO:0090231	regulation of spindle checkpoint

Cellular Component

GO:0000242	pericentriolar material
GO:0000922	spindle pole
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005813	centrosome
GO:0005874	microtubule
GO:0030054	cell junction
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome