Version 5.4
Homo sapiens Gene: RAB8B
Summary
InnateDB Gene IDBG-15716.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAB8B
Gene Name RAB8B, member RAS oncogene family
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000166128
Encoded Proteins
IDBP-15718
RAB8B, member RAS oncogene family
IDBP-591592
RAB8B, member RAS oncogene family
IDBP-595280
RAB8B, member RAS oncogene family
IDBP-599957
RAB8B, member RAS oncogene family
IDBP-585099
RAB8B, member RAS oncogene family
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary RAB proteins, like RAB8B, are low molecular mass monomeric GTPases that localize on the cytoplasmic surfaces of distinct membrane-bound organelles. RAB proteins function in intracellular vesicle transport by aiding in the docking and/or fusion of vesicles with their target membranes (summary by Chen et al., 1997 [PubMed 9030196]).[supplied by OMIM, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:63189469-63267782
Strand Forward strand
Band q22.2
Transcripts
ENST00000321437 ENSP00000312734
ENST00000558990 ENSP00000453236
ENST00000558119 ENSP00000453679
ENST00000559927 ENSP00000453111
ENST00000559006 ENSP00000453982
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0019003 GDP binding
GO:0030911 TPR domain binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006886 intracellular protein transport
GO:0006913 nucleocytoplasmic transport
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0015031 protein transport
GO:0019882 antigen processing and presentation
GO:0031346 positive regulation of cell projection organization
GO:0034332 adherens junction organization
GO:0045046 protein import into peroxisome membrane
GO:0051461 positive regulation of corticotropin secretion
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005778 peroxisomal membrane
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030670 phagocytic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0045335 phagocytic vesicle
GO:0048471 perinuclear region of cytoplasm
GO:0051286 cell tip
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000036943
View Gene Order
ENSBTAG00000011146
Not yet available
Cross-References
SwissProt
TrEMBL H0YLJ8
UniProt Splice Variant
Entrez Gene 51762
UniGene Hs.389733 Hs.598101 Hs.603508 Hs.605196 Hs.718109
RefSeq NM_016530 XM_006720569
HUGO HGNC:30273
OMIM 613532
CCDS CCDS10183
HPRD 11476
IMGT
EMBL AC016207
GenPept
RNA Seq Atlas 51762

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca