InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RAB8B

Summary

InnateDB Protein

IDBP-15718.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAB8B

Protein Name

RAB8B, member RAS oncogene family

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000312734

InnateDB Gene

IDBG-15716 (RAB8B)

Protein Structure

UniProt Annotation

Function

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in polarized vesicular trafficking and neurotransmitter release. May participate in cell junction dynamics in Sertoli cells (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle, phagosome {ECO:0000269PubMed:21255211}. Cytoplasmic vesicle, phagosome membrane {ECO:0000269PubMed:21255211}; Lipid- anchor {ECO:0000269PubMed:21255211}; Cytoplasmic side {ECO:0000269PubMed:21255211}. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019003	GDP binding
GO:0030911	TPR domain binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0006913	nucleocytoplasmic transport
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0019882	antigen processing and presentation
GO:0031346	positive regulation of cell projection organization
GO:0034332	adherens junction organization
GO:0045046	protein import into peroxisome membrane
GO:0051461	positive regulation of corticotropin secretion

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005778	peroxisomal membrane
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030670	phagocytic vesicle membrane
GO:0031410	cytoplasmic vesicle
GO:0045335	phagocytic vesicle
GO:0048471	perinuclear region of cytoplasm
GO:0051286	cell tip
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000795 Elongation factor, GTP-binding domain
IPR001806 Small GTPase superfamily
IPR002041 Ran GTPase
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR006762 Gtr1/RagA G protein
IPR013684 Mitochondrial Rho-like
IPR019009 Signal recognition particle receptor, beta subunit
IPR020849 Small GTPase superfamily, Ras type
IPR024156 Small GTPase superfamily, ARF type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00009
PF00071
PF00025
PF04670
PF08477
PF09439

PRINTS

PR00315
PR00449
PR00627
PR00328

PIRSF

SMART

SM00176
SM00174
SM00175
SM00173
SM00177

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt