Mus musculus Gene: Rnase1
Summary
InnateDB Gene IDBG-157221.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rnase1
Gene Name ribonuclease, RNase A family, 1 (pancreatic)
Synonyms AI574248; Rib-1; Rib1;
Species Mus musculus
Ensembl Gene ENSMUSG00000035896
Encoded Proteins
ribonuclease, RNase A family, 1 (pancreatic)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000129538:
This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3\'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2\',3\'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:51145002-51146767
Strand Reverse strand
Band C1
Transcripts
ENSMUST00000080126 ENSMUSP00000079025
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0005515 protein binding
GO:0016892 endoribonuclease activity, producing 3'-phosphomonoesters
Biological Process
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
Cellular Component
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_011271
OMIM
CCDS CCDS27038
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas