Homo sapiens Gene: RNASE1
Summary
InnateDB Gene IDBG-2384.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNASE1
Gene Name ribonuclease, RNase A family, 1 (pancreatic)
Synonyms RAC1; RIB1; RNS1;
Species Homo sapiens
Ensembl Gene ENSG00000129538
Encoded Proteins
ribonuclease, RNase A family, 1 (pancreatic)
ribonuclease, RNase A family, 1 (pancreatic)
ribonuclease, RNase A family, 1 (pancreatic)
ribonuclease, RNase A family, 1 (pancreatic)
ribonuclease, RNase A family, 1 (pancreatic)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3\'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2\',3\'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:20801228-20803278
Strand Reverse strand
Band q11.2
Transcripts
ENST00000340900 ENSP00000344193
ENST00000397970 ENSP00000381060
ENST00000397967 ENSP00000381057
ENST00000412779 ENSP00000399493
ENST00000555698 ENSP00000451058
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0004522 pancreatic ribonuclease activity
GO:0005515 protein binding
GO:0016892 endoribonuclease activity, producing 3'-phosphomonoesters
Biological Process
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
Cellular Component
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.623499
RefSeq NM_002933 NM_198232 NM_198234 NM_198235
HUGO
OMIM
CCDS CCDS9559
HPRD 01591
IMGT
EMBL
GenPept
RNA Seq Atlas