Version 5.4
Homo sapiens Gene: RNASE1
Summary
InnateDB Gene IDBG-2384.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNASE1
Gene Name ribonuclease, RNase A family, 1 (pancreatic)
Synonyms RAC1; RIB1; RNS1
Species Homo sapiens
Ensembl Gene ENSG00000129538
Encoded Proteins
IDBP-2386
ribonuclease, RNase A family, 1 (pancreatic)
IDBP-234178
ribonuclease, RNase A family, 1 (pancreatic)
IDBP-234180
ribonuclease, RNase A family, 1 (pancreatic)
IDBP-360709
ribonuclease, RNase A family, 1 (pancreatic)
IDBP-593474
ribonuclease, RNase A family, 1 (pancreatic)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3\'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2\',3\'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:20801228-20803278
Strand Reverse strand
Band q11.2
Transcripts
ENST00000340900 ENSP00000344193
ENST00000397970 ENSP00000381060
ENST00000397967 ENSP00000381057
ENST00000412779 ENSP00000399493
ENST00000555698 ENSP00000451058
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0004522 pancreatic ribonuclease activity
GO:0005515 protein binding
GO:0016892 endoribonuclease activity, producing 3'-phosphomonoesters
Biological Process
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
Cellular Component
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000035896
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.623499
RefSeq NM_002933 NM_198232 NM_198234 NM_198235
HUGO
OMIM
CCDS CCDS9559
HPRD 01591
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca