Version 5.4
Mus musculus Gene: Il9
Summary
InnateDB Gene IDBG-157258.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Il9
Gene Name interleukin 9
Synonyms Il-9; P40
Species Mus musculus
Ensembl Gene ENSMUSG00000021538
Encoded Proteins
IDBP-157260
interleukin 9
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21983833
Il9 production is largely restricted to innate lymphoid cells during papain-induce lung inflammation and serves as an as important bridging link to induce type 2 helper T cell responses.
PMID 24138883
Th9 cells and IL-9 have a critical and nonredundant role in host-protective type 2 immunity against parasitic worm infection
InnateDB Annotation from Orthologs
Summary
PMID 21983833
[Homo sapiens] IL9 production is largely restricted to innate lymphoid cells during papain-induce lung inflammation and IL9 serves as an important bridging link to induce type 2 helper T cell responses. (Demonstrated in mice)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145839:
The protein encoded by this gene is a cytokine that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin 9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. The gene encoding this cytokine has been identified as a candidate gene for asthma. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:56479277-56482246
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000022019 ENSMUSP00000022019
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 4 [view]
Protein-DNA 11 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005126 cytokine receptor binding
GO:0005140 interleukin-9 receptor binding
GO:0008083 growth factor activity
Biological Process
GO:0006955 immune response
GO:0030307 positive regulation of cell growth
GO:0045087 innate immune response (InnateDB)
GO:0045407 positive regulation of interleukin-5 biosynthetic process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000145839
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu04630
Jak-STAT signaling pathway pathway
mmu05310
Asthma pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
GPCR signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_20
IL9 pathway
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
hsa05310
Asthma pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt P15247
TrEMBL
UniProt Splice Variant
Entrez Gene 16198
UniGene Mm.3006
RefSeq NM_008373
OMIM
CCDS CCDS26562
HPRD
IMGT
MGI ID MGI:96563
MGI Symbol Il9
EMBL M30136 X14045
GenPept AAA39874 CAA32203
RNA Seq Atlas 16198

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca