InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: IL9

Summary

InnateDB Gene

IDBG-45710.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL9

Gene Name

interleukin 9

Synonyms

HP40; IL-9; P40

Species

Homo sapiens

Ensembl Gene

ENSG00000145839

Encoded Proteins

IDBP-45712

interleukin 9

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21983833

IL9 production is largely restricted to innate lymphoid cells during papain-induce lung inflammation and IL9 serves as an important bridging link to induce type 2 helper T cell responses. (Demonstrated in mice)

InnateDB Annotation from Orthologs

Summary

PMID 21983833

[Mus musculus] Il9 production is largely restricted to innate lymphoid cells during papain-induce lung inflammation and serves as an as important bridging link to induce type 2 helper T cell responses.

PMID 24138883

[Mus musculus] Th9 cells and IL-9 have a critical and nonredundant role in host-protective type 2 immunity against parasitic worm infection

Entrez Gene

Summary

The protein encoded by this gene is a cytokine that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin 9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. The gene encoding this cytokine has been identified as a candidate gene for asthma. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:135892246-135895827

Strand

Reverse strand

Band

q31.1

Transcripts

ENST00000274520

ENSP00000274520

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	2 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005126	cytokine receptor binding
GO:0005140	interleukin-9 receptor binding
GO:0008083	growth factor activity

Biological Process

GO:0006954	inflammatory response
GO:0006955	immune response
GO:0008284	positive regulation of cell proliferation
GO:0030307	positive regulation of cell growth
GO:0045087	innate immune response (InnateDB)
GO:0045407	positive regulation of interleukin-5 biosynthetic process

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000021538

View Gene Order

Pathways

NETPATH

NetPath_20

IL9 pathway

REACTOME

KEGG

hsa04060

Cytokine-cytokine receptor interaction pathway

hsa04630

Jak-STAT signaling pathway pathway

hsa05310

Asthma pathway

INOH

INOH website

JAK STAT pathway and regulation pathway

INOH website

GPCR signaling pathway

PID NCI

Cross-References

SwissProt

P15248

TrEMBL

UniProt Splice Variant

Entrez Gene

3578

UniGene

RefSeq

NM_000590

HUGO

HGNC:6029

OMIM

146931

CCDS

CCDS4189

HPRD

00910

IMGT

EMBL

AC002428 AC004763 AF361105 BC066283 BC066285 BC066286 M30134 M30135 M86593 S63356 X17543

GenPept

AAA35887 AAA36400 AAA59161 AAB19823 AAB66904 AAC17735 AAH66283 AAH66285 AAH66286 AAK26666 CAA35581

RNA Seq Atlas

3578