Version 5.4
Mus musculus Gene: Gldc
Summary
InnateDB Gene IDBG-157787.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gldc
Gene Name glycine decarboxylase
Synonyms D030049L12Rik; D19Wsu57e
Species Mus musculus
Ensembl Gene ENSMUSG00000024827
Encoded Proteins
IDBP-157791
glycine decarboxylase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000178445:
Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).[provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:30098449-30175418
Strand Reverse strand
Band C1
Transcripts
ENSMUST00000025778 ENSMUSP00000025778
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004375 glycine dehydrogenase (decarboxylating) activity
GO:0016829 lyase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0006520 cellular amino acid metabolic process
GO:0006544 glycine metabolic process
GO:0006546 glycine catabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000178445
View Gene Order
ENSBTAG00000025903
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00260
Glycine, serine and threonine metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00260
Glycine, serine and threonine metabolism pathway
INOH
INOH website
Glycine Serine metabolism pathway
PID NCI
Cross-References
SwissProt Q91W43
TrEMBL
UniProt Splice Variant
Entrez Gene 104174
UniGene Mm.274852 Mm.406077
RefSeq NM_138595
OMIM
CCDS CCDS37956
HPRD
IMGT
MGI ID MGI:1341155
MGI Symbol Gldc
EMBL BC017135
GenPept AAH17135
RNA Seq Atlas 104174

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca