Version 5.4
Mus musculus Gene: Prrg1
Summary
InnateDB Gene IDBG-158068.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Prrg1
Gene Name proline rich Gla (G-carboxyglutamic acid) 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000047996
Encoded Proteins
IDBP-252641
proline rich Gla (G-carboxyglutamic acid) 1
IDBP-252654
proline rich Gla (G-carboxyglutamic acid) 1
IDBP-538707
proline rich Gla (G-carboxyglutamic acid) 1
IDBP-715633
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130962:
This gene encodes a vitamin K-dependent, gamma-carboxyglutamic acid (Gla)-containing, single-pass transmembrane protein. This protein contains a Gla domain at the N-terminus, preceded by a propeptide sequence required for post-translational gamma-carboxylation of specific glutamic acid residues by a vitamin K-dependent gamma-carboxylase. The C-terminus is proline-rich containing PPXY and PXXP motifs found in a variety of signaling and cytoskeletal proteins. This gene is highly expressed in the spinal cord. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:78449613-78583896
Strand Reverse strand
Band B
Transcripts
ENSMUST00000114025 ENSMUSP00000109659
ENSMUST00000114024 ENSMUSP00000109658
ENSMUST00000126209
ENSMUST00000126994
ENSMUST00000156427
ENSMUST00000134602 ENSMUSP00000117104
ENSMUST00000148345
ENSMUST00000132852
ENSMUST00000137011
ENSMUST00000177904 ENSMUSP00000136713
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005509 calcium ion binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005575 cellular_component
GO:0005576 extracellular region
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000130962
View Gene Order
ENSBTAG00000047536
Not yet available
Cross-References
SwissProt
TrEMBL A2BFE8 A2BFE9
UniProt Splice Variant
Entrez Gene 546336
UniGene
RefSeq NM_001289683 XM_006528141 XM_006528143 XM_006528145 XM_006528146 NM_001164275 NM_027322 XM_006528147
OMIM
CCDS CCDS53121
HPRD
IMGT
MGI ID MGI:1917364
MGI Symbol Prrg1
EMBL AL672300 BX284111
GenPept
RNA Seq Atlas 546336

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca