Version 5.4
Homo sapiens Gene: PRRG1
Summary
InnateDB Gene IDBG-55598.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRRG1
Gene Name proline rich Gla (G-carboxyglutamic acid) 1
Synonyms PRGP1
Species Homo sapiens
Ensembl Gene ENSG00000130962
Encoded Proteins
IDBP-55600
proline rich Gla (G-carboxyglutamic acid) 1
IDBP-366800
proline rich Gla (G-carboxyglutamic acid) 1
IDBP-474077
proline rich Gla (G-carboxyglutamic acid) 1
IDBP-480224
proline rich Gla (G-carboxyglutamic acid) 1
IDBP-482912
proline rich Gla (G-carboxyglutamic acid) 1
IDBP-593070
proline rich Gla (G-carboxyglutamic acid) 1
IDBP-601419
proline rich Gla (G-carboxyglutamic acid) 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a vitamin K-dependent, gamma-carboxyglutamic acid (Gla)-containing, single-pass transmembrane protein. This protein contains a Gla domain at the N-terminus, preceded by a propeptide sequence required for post-translational gamma-carboxylation of specific glutamic acid residues by a vitamin K-dependent gamma-carboxylase. The C-terminus is proline-rich containing PPXY and PXXP motifs found in a variety of signaling and cytoskeletal proteins. This gene is highly expressed in the spinal cord. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:37349275-37457295
Strand Forward strand
Band p21.1
Transcripts
ENST00000378628 ENSP00000367894
ENST00000449135 ENSP00000390332
ENST00000491253
ENST00000466533 ENSP00000418384
ENST00000484460 ENSP00000420353
ENST00000463135 ENSP00000419999
ENST00000470290
ENST00000542554 ENSP00000444278
ENST00000543642 ENSP00000443271
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
Biological Process
Cellular Component
GO:0005576 extracellular region
GO:0005887 integral component of plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000047996
View Gene Order
ENSBTAG00000047536
Not yet available
Cross-References
SwissProt O14668
TrEMBL C9J6P5 C9JNY5
UniProt Splice Variant
Entrez Gene 5638
UniGene Hs.190341 Hs.596785
RefSeq NM_001173490 NM_000950 NM_001142395 NM_001173486 NM_001173489
HUGO HGNC:9469
OMIM 604428
CCDS CCDS14239 CCDS55397
HPRD 05113
IMGT
EMBL AF009242 AK312904 AL356858 BC041591 BC060833 CH471141
GenPept AAB67070 AAH60833 BAG35750 CAI40412 EAW59457 EAW59458
RNA Seq Atlas 5638

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca