Homo sapiens Gene: PRRG1
Summary
InnateDB Gene IDBG-55598.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRRG1
Gene Name proline rich Gla (G-carboxyglutamic acid) 1
Synonyms PRGP1;
Species Homo sapiens
Ensembl Gene ENSG00000130962
Encoded Proteins
proline rich Gla (G-carboxyglutamic acid) 1
proline rich Gla (G-carboxyglutamic acid) 1
proline rich Gla (G-carboxyglutamic acid) 1
proline rich Gla (G-carboxyglutamic acid) 1
proline rich Gla (G-carboxyglutamic acid) 1
proline rich Gla (G-carboxyglutamic acid) 1
proline rich Gla (G-carboxyglutamic acid) 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a vitamin K-dependent, gamma-carboxyglutamic acid (Gla)-containing, single-pass transmembrane protein. This protein contains a Gla domain at the N-terminus, preceded by a propeptide sequence required for post-translational gamma-carboxylation of specific glutamic acid residues by a vitamin K-dependent gamma-carboxylase. The C-terminus is proline-rich containing PPXY and PXXP motifs found in a variety of signaling and cytoskeletal proteins. This gene is highly expressed in the spinal cord. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:37349275-37457295
Strand Forward strand
Band p21.1
Transcripts
ENST00000378628 ENSP00000367894
ENST00000449135 ENSP00000390332
ENST00000491253
ENST00000466533 ENSP00000418384
ENST00000484460 ENSP00000420353
ENST00000463135 ENSP00000419999
ENST00000470290
ENST00000542554 ENSP00000444278
ENST00000543642 ENSP00000443271
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
Biological Process
Cellular Component
GO:0005576 extracellular region
GO:0005887 integral component of plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.190341 Hs.596785
RefSeq NM_000950 NM_001142395 NM_001173486 NM_001173489 NM_001173490
HUGO
OMIM
CCDS CCDS14239 CCDS55397
HPRD 05113
IMGT
EMBL
GenPept
RNA Seq Atlas