Version 5.4
| Mus musculus Gene: Fance | |||||||
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| Summary | |||||||
| InnateDB Gene | IDBG-158146.6 | ||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
| Gene Symbol | Fance | ||||||
| Gene Name | Fanconi anemia, complementation group E | ||||||
| Synonyms | 2810451D06Rik; AI415634; AW209126 | ||||||
| Species | Mus musculus | ||||||
| Ensembl Gene | ENSMUSG00000007570 | ||||||
| Encoded Proteins |
Fanconi anemia, complementation group E
Fanconi anemia, complementation group E
Fanconi anemia, complementation group E
Fanconi anemia, complementation group E
Fanconi anemia, complementation group E
Fanconi anemia, complementation group E
Fanconi anemia, complementation group E
Fanconi anemia, complementation group E
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| Protein Structure | |||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||
| Entrez Gene | |||||||
| Summary |
This gene encodes the complementation group E subunit of the multimeric Fanconi anemia (FA) nuclear complex composed of proteins encoded by over ten Fanconi anemia complementation (FANC) group genes: FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The FA complex is necessary for protection against DNA damage. This gene product is required for the nuclear accumulation of FANCC and provides a critical bridge between the FA complex and FANCD2. Defects in the related human gene are a cause of Fanconi anemia, a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. Translation of this protein is initiated at a non-AUG (CUG) start codon, which is inferred from the related human gene and the notion that this protein is functionally indispensable. Multiple transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2009] |
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| Gene Information | |||||||
| Type | Protein coding | ||||||
| Genomic Location | Chromosome 17:28313530-28326568 | ||||||
| Strand | Forward strand | ||||||
| Band | A3.3 | ||||||
| Transcripts | |||||||
| Interactions | |||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathway Predictions based on Human Orthology Data | |||||||
| NETPATH | |||||||
| REACTOME |
Fanconi Anemia pathway pathway
DNA Repair pathway
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| KEGG | |||||||
| INOH | |||||||
| PID NCI |
Fanconi anemia pathway
BARD1 signaling events
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| Cross-References | |||||||
| SwissProt | |||||||
| TrEMBL | B8JJD1 B8JJD2 B8JJD3 B8JJD5 B8JJD6 B8JJD7 B8JJD8 Q8R3Z2 | ||||||
| UniProt Splice Variant | |||||||
| Entrez Gene | 72775 | ||||||
| UniGene | Mm.201859 | ||||||
| RefSeq | NM_001163819 NM_001163820 | ||||||
| OMIM | |||||||
| CCDS | |||||||
| HPRD | |||||||
| IMGT | |||||||
| MGI ID | MGI:1920025 | ||||||
| MGI Symbol | Fance | ||||||
| EMBL | BC016538 CH466606 CT025652 | ||||||
| GenPept | AAH16538 EDL22566 | ||||||
| RNA Seq Atlas | 72775 | ||||||