Version 5.4
| Homo sapiens Gene: CA12 | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-15824.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | CA12 | ||||||||||||||||||
| Gene Name | carbonic anhydrase XII | ||||||||||||||||||
| Synonyms | CAXII; HsT18816 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000074410 | ||||||||||||||||||
| Encoded Proteins |
carbonic anhydrase XII
carbonic anhydrase XII
carbonic anhydrase XII
|
||||||||||||||||||
| Protein Structure |
|
||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. This gene product is a type I membrane protein that is highly expressed in normal tissues, such as kidney, colon and pancreas, and has been found to be overexpressed in 10% of clear cell renal carcinomas. Two transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. This gene product is a type I membrane protein that is highly expressed in normal tissues, such as kidney, colon and pancreas, and has been found to be overexpressed in 10%% of clear cell renal carcinomas. Three transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2014] |
||||||||||||||||||
| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 15:63321378-63382161 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | q22.2 | ||||||||||||||||||
| Transcripts |
|
||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
|
||||||||||||||||||
| Gene Ontology | |||||||||||||||||||
Molecular Function |
|
||||||||||||||||||
| Biological Process |
|
||||||||||||||||||
| Cellular Component |
|
||||||||||||||||||
| Orthologs | |||||||||||||||||||
|
Species
Mus musculus
Bos taurus
|
Gene ID
Gene Order
Not yet available
|
||||||||||||||||||
| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Reversible hydration of carbon dioxide pathway
Metabolism pathway
|
||||||||||||||||||
| KEGG |
Nitrogen metabolism pathway
|
||||||||||||||||||
| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | O43570 | ||||||||||||||||||
| TrEMBL | B3KUB4 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 771 | ||||||||||||||||||
| UniGene | Hs.210995 Hs.604455 Hs.609263 Hs.695438 Hs.734678 | ||||||||||||||||||
| RefSeq | NM_001218 NM_206925 | ||||||||||||||||||
| HUGO | HGNC:1371 | ||||||||||||||||||
| OMIM | 603263 | ||||||||||||||||||
| CCDS | CCDS10185 CCDS10186 | ||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AC016207 AC087525 AF037335 AF051882 AK096845 BC000278 BC011691 BC023981 BT006656 CH471082 | ||||||||||||||||||
| GenPept | AAC39789 AAC63952 AAH00278 AAH11691 AAH23981 AAP35302 BAG53376 EAW77649 | ||||||||||||||||||
| RNA Seq Atlas | 771 | ||||||||||||||||||