InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Car12

Summary

InnateDB Gene

IDBG-179857.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Car12

Gene Name

carbonic anyhydrase 12

Synonyms

2310047E01Rik; AI314958; Ca12

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032373

Encoded Proteins

IDBP-179859

carbonic anyhydrase 12

IDBP-179861

carbonic anyhydrase 12

IDBP-532648

carbonic anyhydrase 12

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000074410:
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. This gene product is a type I membrane protein that is highly expressed in normal tissues, such as kidney, colon and pancreas, and has been found to be overexpressed in 10% of clear cell renal carcinomas. Two transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. This gene product is a type I membrane protein that is highly expressed in normal tissues, such as kidney, colon and pancreas, and has been found to be overexpressed in 10%% of clear cell renal carcinomas. Three transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:66713686-66766845

Strand

Forward strand

Band

Transcripts

ENSMUST00000071889	ENSMUSP00000071786
ENSMUST00000085420	ENSMUSP00000082541
ENSMUST00000152011
ENSMUST00000123195
ENSMUST00000134829	ENSMUSP00000118030

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	1 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004089	carbonate dehydratase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006730	one-carbon metabolic process
GO:0006885	regulation of pH
GO:0008152	metabolic process
GO:0015670	carbon dioxide transport

Cellular Component

GO:0005575	cellular_component
GO:0016021	integral component of membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000074410

View Gene Order

ENSBTAG00000019390

Not yet available

Pathways

NETPATH

REACTOME

REACT_188937

Metabolism pathway

REACT_199096

Reversible hydration of carbon dioxide pathway

KEGG

mmu00910

Nitrogen metabolism pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_121123

Reversible hydration of carbon dioxide pathway

REACT_111217

Metabolism pathway

KEGG

hsa00910

Nitrogen metabolism pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.277921

RefSeq

NM_178396 XM_006511548 XM_006511549

OMIM

CCDS

CCDS23306

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas