Mus musculus Gene: Dna2
Summary
InnateDB Gene IDBG-158343.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dna2
Gene Name DNA replication helicase 2 homolog (yeast)
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000036875
Encoded Proteins
DNA replication helicase 2 homolog (yeast)
DNA replication helicase 2 homolog (yeast)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138346:
DNA2 is a conserved helicase/nuclease involved in the maintenance of mitochondrial and nuclear DNA stability (Duxin et al., 2009 [PubMed 19487465]).[supplied by OMIM, Nov 2010]
This gene encodes a member of the DNA2/NAM7 helicase family. The encoded protein is a conserved helicase/nuclease involved in the maintenance of mitochondrial and nuclear DNA stability. Mutations in this gene are associated with autosomal dominant progressive external ophthalmoplegia-6 (PEOA6) and Seckel syndrome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:62947026-62974185
Strand Forward strand
Band B4
Transcripts
ENSMUST00000092462 ENSMUSP00000090119
ENSMUST00000131422 ENSMUSP00000115750
ENSMUST00000131715
ENSMUST00000129785
ENSMUST00000139212
ENSMUST00000137378
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0004518 nuclease activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016890 site-specific endodeoxyribonuclease activity, specific for altered base
GO:0017108 5'-flap endonuclease activity
GO:0043139 5'-3' DNA helicase activity
GO:0043142 single-stranded DNA-dependent ATPase activity
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0000076 DNA replication checkpoint
GO:0000729 DNA double-strand break processing
GO:0000737 DNA catabolic process, endonucleolytic
GO:0006200 ATP catabolic process
GO:0006260 DNA replication
GO:0006264 mitochondrial DNA replication
GO:0006284 base-excision repair
GO:0032508 DNA duplex unwinding
GO:0033567 DNA replication, Okazaki fragment processing
GO:0043137 DNA replication, removal of RNA primer
GO:0043504 mitochondrial DNA repair
GO:0045740 positive regulation of DNA replication
Cellular Component
GO:0005634 nucleus
GO:0005760 gamma DNA polymerase complex
GO:0042645 mitochondrial nucleoid
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Processive synthesis on the lagging strand pathway
Removal of the Flap Intermediate pathway
Cell Cycle, Mitotic pathway
Chromosome Maintenance pathway
Synthesis of DNA pathway
DNA strand elongation pathway
DNA Replication pathway
Telomere Maintenance pathway
Cell Cycle pathway
Removal of the Flap Intermediate from the C-strand pathway
Telomere C-strand (Lagging Strand) Synthesis pathway
Extension of Telomeres pathway
Processive synthesis on the C-strand of the telomere pathway
Lagging Strand Synthesis pathway
S Phase pathway
KEGG
DNA replication pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
DNA Replication pathway
Telomere C-strand (Lagging Strand) Synthesis pathway
Synthesis of DNA pathway
Removal of the Flap Intermediate from the C-strand pathway
Removal of the Flap Intermediate pathway
S Phase pathway
Chromosome Maintenance pathway
Telomere Maintenance pathway
Cell Cycle pathway
Processive synthesis on the lagging strand pathway
Cell Cycle, Mitotic pathway
DNA strand elongation pathway
Processive synthesis on the C-strand of the telomere pathway
Extension of Telomeres pathway
Lagging Strand Synthesis pathway
S Phase pathway
Extension of Telomeres pathway
Removal of the Flap Intermediate from the C-strand pathway
DNA Replication pathway
Telomere Maintenance pathway
Removal of the Flap Intermediate pathway
Cell Cycle, Mitotic pathway
Telomere C-strand (Lagging Strand) Synthesis pathway
Processive synthesis on the lagging strand pathway
Processive synthesis on the C-strand of the telomere pathway
Synthesis of DNA pathway
Cell Cycle pathway
Lagging Strand Synthesis pathway
Chromosome Maintenance pathway
DNA strand elongation pathway
KEGG
DNA replication pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.21492
RefSeq NM_177372
OMIM
CCDS CCDS35923
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas